Kawamura H, Wakabayashi T, Yamaguchi S, Taniguchi T, Takayanagi N
Natl Inst Anim Health Q (Tokyo). 1976 Winter;16(4):135-40.
Two-day-old chicks were inoculated with one or ten doses of Marek's disease (MD) vaccine originated from the herpesvirus of turkeys (HVT) and contaminated with a reticuloendotheliosis virus (REV). As a result, they presented such symptoms as abnormality in the vane of remiges, undergrowth, anemia, and leg paralysis. These symptoms were the same as those induced by the same vaccine among chicks in the field. Control chicks which had been placed in the same house as those inoculated with the vaccine exhibited no abnormal signs. A persistent infection with REV was noticed in the vaccine-inoculated group. A horizontal infection with REV was the highest in the control group, which was followed by the group inoculated with one dose and that inoculated with ten doses in the order listed. The antibody response of chicks to HVT and MD virus was also inhibited by REV.
给两日龄雏鸡接种一剂或十剂源自火鸡疱疹病毒（HVT）且污染了网状内皮组织增殖症病毒（REV）的马立克氏病（MD）疫苗。结果，它们出现了飞羽羽片异常、生长发育不良、贫血和腿部麻痹等症状。这些症状与该疫苗在实际养殖环境中雏鸡身上引发的症状相同。与接种疫苗的雏鸡置于同一鸡舍的对照雏鸡未表现出异常迹象。在接种疫苗的组中发现了REV的持续感染。REV的水平传播在对照组中最高，其次是接种一剂疫苗的组，然后是接种十剂疫苗的组，顺序依次排列。REV也抑制了雏鸡对HVT和MD病毒的抗体反应。
