Noble Earl G, Milne Kevin J, Melling C W James
School of Kinesiology, Faculty of Health Sciences, University of Western Ontario, London, ON N6A3K7, Canada.
Appl Physiol Nutr Metab. 2008 Oct;33(5):1050-65. doi: 10.1139/H08-069.
Heat shock proteins (HSPs) are, in general, prosurvival molecules within the cellular environment, and the overexpression of even just 1 family of HSPs can lead to protection against and improvements after a variety of stressors. Not surprisingly, a fertile area of study has grown out of efforts to exploit the innate biologic behaviour of HSPs. Exercise, because of the inherent physiologic stresses associated with it, is but 1 stimulus that can result in a robust increase in various HSPs in several tissues, not the least of which happen to be the heart and skeletal muscle. The purpose of this review is to introduce the reader to the major HSP families, the control of their expression, and some of their biologic functions, specifically with respect to the influence of exercise. Moreover, as the first in a series of reviews from a common symposium, we will briefly introduce the concepts presented by the other authors, which include the effects of different exercise paradigms on skeletal muscle HSPs in the adult and aged systems, HSPs as regulators of inflammation, and the ion channel stabilizing effects of HSPs.
热休克蛋白（HSPs）通常是细胞环境中的促生存分子，即使仅一个热休克蛋白家族的过表达也能在各种应激源作用后起到保护和改善作用。毫不奇怪，利用热休克蛋白的固有生物学行为的研究领域蓬勃发展。运动因其相关的内在生理应激，是一种能导致多种组织中各种热休克蛋白显著增加的刺激因素，其中尤其包括心脏和骨骼肌。本综述的目的是向读者介绍主要的热休克蛋白家族、其表达调控以及一些生物学功能，特别是关于运动的影响。此外，作为同一研讨会系列综述中的第一篇，我们将简要介绍其他作者提出的概念，包括不同运动模式对成年和老年系统骨骼肌热休克蛋白的影响、热休克蛋白作为炎症调节剂以及热休克蛋白对离子通道的稳定作用。
