Basen-Engquist Karen, Hughes Daniel, Perkins Heidi, Shinn Eileen, Taylor Cindy Carmack
Department of Behavioral Science, The University of Texas M. D. Anderson Cancer Center, P.O. Box 301439, Unit 1330, Houston, TX 77230-1439, USA.
J Cancer Surviv. 2008 Dec;2(4):253-61. doi: 10.1007/s11764-008-0067-9. Epub 2008 Oct 16.
Many breast cancer survivors experience long term sequelae, including fatigue, decreased physical functioning, pain, and psychological distress. Physical activity can ameliorate these problems, but there is little research on how activity should be performed to be most beneficial. This study explores how dimensions of physical activity (total energy expenditure, frequency, and duration) are associated with symptoms among breast cancer survivors.
We conducted a secondary analysis of data on physical activity behavior and symptoms in a cross-sectional study (n = 148) of breast cancer survivors who were off treatment and had been diagnosed within the past 5 years.
Multivariate analyses showed that total energy expenditure was associated with better general health (p = 0.006) and fewer depressive symptoms (p = 0.014), while frequency of activity was linearly related to physical functioning (p = 0.047), pain (0.057), general health (p < 0.001), and depressive symptoms (p < 0.001). Duration was related to physical functioning, pain, and general health, but the worst outcomes were reported by the participants with the shortest and longest duration of activity (quadratic trend p values = 0.002, 0.003, 0.008, respectively).
DISCUSSION/CONCLUSIONS: Greater total energy expenditure, higher physical activity frequency, and moderate duration were associated with better outcomes for most symptoms, although there was no relationship between any of the dimensions of physical activity and fatigue.
The association of better outcomes with higher energy expenditure, higher frequency of activity, and moderate duration indicates that increasing activity through multiple short bouts may be the most beneficial for breast cancer survivors. However, randomized studies are needed to confirm this finding.
许多乳腺癌幸存者会经历长期后遗症，包括疲劳、身体机能下降、疼痛和心理困扰。体育活动可以改善这些问题，但关于如何进行活动才能达到最大益处的研究很少。本研究探讨体育活动的各个维度（总能量消耗、频率和持续时间）与乳腺癌幸存者症状之间的关联。
我们对一项横断面研究（n = 148）中的体育活动行为和症状数据进行了二次分析，该研究的对象是已停止治疗且在过去5年内被诊断出患有乳腺癌的幸存者。
多变量分析显示，总能量消耗与更好的总体健康状况（p = 0.006）和较少的抑郁症状（p = 0.014）相关，而活动频率与身体机能（p = 0.047）、疼痛（0.057）、总体健康状况（p < 0.001）和抑郁症状（p < 0.001）呈线性相关。持续时间与身体机能、疼痛和总体健康状况有关，但活动持续时间最短和最长的参与者报告的结果最差（二次趋势p值分别为0.002、0.003、0.008）。
讨论/结论：尽管体育活动的任何维度与疲劳之间均无关联，但更高的总能量消耗、更高的体育活动频率和适度的持续时间与大多数症状的更好结果相关。
更好的结果与更高的能量消耗、更高的活动频率和适度的持续时间之间的关联表明，通过多次短时间活动来增加活动量可能对乳腺癌幸存者最为有益。然而，需要进行随机研究来证实这一发现。
