Berger Ann M, Visovsky Constance, Hertzog Melody, Holtz Shandra, Loberiza Fausto R
College of Nursing, University of Nebraska Medical Center, Omaha, NE, USA.
J Support Oncol. 2012 May-Jun;10(3):112-8. doi: 10.1016/j.suponc.2011.11.001. Epub 2012 Jan 24.
Breast cancer survivors receive routine medical follow-up but are screened less frequently to detect symptom severity and interference with function in daily life.
Among breast cancer survivors, we describe the usual and worst severity of 5 common symptoms and the extent to which these symptoms interfere with general activity and enjoyment of life, we determine the associations among symptoms and the interference items, and we explore associations of interference with function and the most prevalent symptoms.
The cross-sectional, descriptive 1-page Breast Cancer Survivor Symptom Survey was mailed to breast cancer survivors identified in a clinical database (ONCOBASE). In total, 184/457 (40.3%) surveys were returned and 162 (35.4%) were used. Participants recorded usual and worst severity of 5 symptoms (fatigue, disturbed sleep, pain, distress, and numbness/tingling) and symptom interference with general activity and enjoyment of life during the past 7 days.
Participants reported usual symptom severity as mild and highest for sleep disturbance, followed by fatigue, distress, numbness/tingling, and pain. Participants recorded worst sleep disturbance and fatigue as moderately severe. Higher pain and fatigue were associated with all other symptoms, whereas disturbed sleep and distress were related to all except numbness/tingling. All symptoms interfered with general activity and enjoyment of life. Pain and numbness/tingling were associated with lower function and disturbed sleep, and made a unique contribution to fatigue.
Limitations of the study include relatively low response and use of a modification of an established scale.
Symptoms often coexisted and contributed to interference with daily function. Pain was most consistently associated with interference with function and severity of other symptoms.
乳腺癌幸存者接受常规医学随访，但较少接受筛查以检测症状严重程度及对日常生活功能的影响。
在乳腺癌幸存者中，我们描述5种常见症状的通常和最严重程度，以及这些症状对一般活动和生活乐趣的影响程度，我们确定症状与干扰项目之间的关联，并探索干扰与功能及最常见症状之间的关联。
将横断面描述性1页的乳腺癌幸存者症状调查问卷邮寄给临床数据库（ONCOBASE）中识别出的乳腺癌幸存者。总共回收了184/457份（40.3%）调查问卷，其中162份（35.4%）被采用。参与者记录了5种症状（疲劳、睡眠障碍、疼痛、苦恼和麻木/刺痛）的通常和最严重程度，以及过去7天症状对一般活动和生活乐趣的干扰情况。
参与者报告通常症状严重程度为轻度，睡眠障碍最高，其次是疲劳、苦恼、麻木/刺痛和疼痛。参与者记录的最严重睡眠障碍和疲劳为中度严重。较高的疼痛和疲劳与所有其他症状相关，而睡眠障碍和苦恼与除麻木/刺痛外的所有症状相关。所有症状均干扰一般活动和生活乐趣。疼痛和麻木/刺痛与较低的功能和睡眠障碍相关，并对疲劳有独特影响。
本研究的局限性包括相对较低的回复率以及使用了既定量表的修改版。
症状常同时存在并导致对日常功能的干扰。疼痛最常与功能干扰和其他症状的严重程度相关。
