Alfano Catherine M, Smith Ashley Wilder, Irwin Melinda L, Bowen Deborah J, Sorensen Bess, Reeve Bryce B, Meeske Kathleen A, Bernstein Leslie, Baumgartner Kathy B, Ballard-Barbash Rachel, Malone Kathleen E, McTiernan Anne
Comprehensive Cancer Center and School of Public Health, The Ohio State University, Columbus, OH, USA.
J Cancer Surviv. 2007 Jun;1(2):116-28. doi: 10.1007/s11764-007-0014-1.
Many breast cancer survivors experience persistent physical symptoms of cancer and treatment that can decrease health-related quality of life (HRQOL). This prospective study investigated physical activity (PA), occurrence of physical symptoms, and HRQOL in a large, ethnically-diverse cohort of breast cancer survivors.
Survivors (n = 545), on average 6 months post-diagnosis, were assessed in person or by mail at baseline (retrospective reports of pre-diagnosis PA), at 29 months post-diagnosis (post-diagnosis PA), and at 39 months post-diagnosis (pain, hormone symptoms, sexual interest/dysfunction, fatigue, physical subscales of HRQOL). Linear regression and analysis of covariance assessed the relationships between pre- and post-diagnosis PA and PA change after cancer with symptoms and HRQOL.
Greater pre-diagnosis PA was associated with better physical functioning at 39 months (betas 1.1-2.3; all p < 0.01) but was generally unrelated to symptoms. Greater post-diagnosis sports/recreational PA was related to less fatigue and better physical functioning (betas -0.146, 2.21; both p < 0.01). Increased PA after cancer was related to less fatigue and pain and better physical functioning (all p < 0.01). Significant positive associations were found for moderate to vigorous and vigorous sports/recreation PA, not household activity. Results were similar for Hispanic and non-Hispanic White women.
DISCUSSION/CONCLUSIONS: Increased PA, especially after cancer, was consistently related to better physical functioning and to reduced fatigue and bodily pain, underscoring the need for PA promotion among survivors.
Survivors may be able to decrease fatigue and bodily pain and be better able to pursue daily activities through increasing recreational PA after cancer.
许多乳腺癌幸存者经历着癌症及其治疗带来的持续身体症状，这些症状会降低与健康相关的生活质量（HRQOL）。这项前瞻性研究调查了一个种族多样化的大型乳腺癌幸存者队列中的身体活动（PA）、身体症状的发生情况以及HRQOL。
平均在确诊后6个月的幸存者（n = 545）在基线时（确诊前PA的回顾性报告）、确诊后29个月（确诊后PA）以及确诊后39个月（疼痛、激素症状、性兴趣/功能障碍、疲劳、HRQOL的身体分量表）接受了面对面或邮寄评估。线性回归和协方差分析评估了确诊前后PA以及癌症后PA变化与症状和HRQOL之间的关系。
确诊前较高的PA与39个月时更好的身体功能相关（β值为1.1 - 2.3；所有p < 0.01），但通常与症状无关。确诊后较高的运动/娱乐PA与较少的疲劳和更好的身体功能相关（β值分别为 -0.146、2.21；两者p < 0.01）。癌症后PA增加与较少的疲劳和疼痛以及更好的身体功能相关（所有p < 0.01）。在中度至剧烈和剧烈运动/娱乐PA方面发现了显著的正相关，而家务活动则不然。西班牙裔和非西班牙裔白人女性的结果相似。
讨论/结论：PA增加，尤其是在癌症后，一直与更好的身体功能以及减少的疲劳和身体疼痛相关，这突出了在幸存者中推广PA的必要性。
幸存者或许能够通过在癌症后增加娱乐性PA来减少疲劳和身体疼痛，并更好地进行日常活动。
