Kumar Dhavendra
Institute of Medical Genetics, University Hospital of Wales, Cardiff University, Cardiff, CF14 4XN, UK,
Genomic Med. 2007;1(3-4):95-104. doi: 10.1007/s11568-007-9013-6. Epub 2007 Dec 18.
The concept of 'evidence-based medicine' dates back to mid-19th century or even earlier. It remains pivotal in planning, funding and in delivering the health care. Clinicians, public health practitioners, health commissioners/purchasers, health planners, politicians and public seek formal 'evidence' in approving any form of health care provision. Essentially 'evidence-based medicine' aims at the conscientious, explicit and judicious use of the current best evidence in making decisions about the care of individual patients. It is in fact the 'personalised medicine' in practice. Since the completion of the human genome project and the rapid accumulation of huge amount of data, scientists and physicians alike are excited on the prospect of 'personalised health care' based on individual's genotype and phenotype. The first decade of the new millennium now witnesses the transition from 'evidence-based medicine' to the 'genomic medicine'. The practice of medicine, including health promotion and prevention of disease, stands now at a wide-open road as the scientific and medical community embraces itself with the rapidly expanding and revolutionising field of genomic medicine. This article reviews the rapid transformation of modern medicine from the 'evidence-based medicine' to 'genomic medicine'.
“循证医学”的概念可追溯到19世纪中叶甚至更早。它在医疗保健的规划、资金投入及提供方面仍然至关重要。临床医生、公共卫生从业者、卫生专员/采购方、卫生规划者、政治家及公众在批准任何形式的医疗保健服务时都寻求正式的“证据”。本质上，“循证医学”旨在在为个体患者的护理做决策时审慎、明确且明智地运用当前最佳证据。实际上，它就是实践中的“个性化医疗”。自人类基因组计划完成以及大量数据迅速积累以来，科学家和医生都对基于个体基因型和表型的“个性化医疗保健”前景感到兴奋。新千年的第一个十年见证了从“循证医学”到“基因组医学”的转变。随着科学界和医学界欣然接纳迅速发展且正在变革的基因组医学领域，医学实践，包括健康促进和疾病预防，如今正处于一条广阔开放的道路上。本文回顾了现代医学从“循证医学”到“基因组医学”的快速转变。
