Liu Chia-Chia, Tsai Shang-Shyue, Chiu Hui-Fen, Wu Trong-Neng, Chen Chih-Cheng, Yang Chun-Yuh
Institute of Occupational Safety and Health, College of Health Sciences, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan.
Inhal Toxicol. 2009 Jan;21(1):48-54. doi: 10.1080/08958370802207326.
To investigate the relationship between air pollution and risk of death from bladder cancer, the authors conducted a matched case-control study using deaths that occurred in Taiwan from 1995 through 2005. Data on all eligible bladder cancer deaths were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. The control group consisted of people who died from causes other than cancer or diseases associated with genitourinary problems. The controls were pair matched to the cases by sex, year of birth, and year of death. Each matched control was selected randomly from the set of possible controls for each case. Classification of exposure to municipality air pollution was based on the measured levels of nitrogen dioxide and sulfur dioxide. The results of the present study show that there is a significant positive association between the levels of air pollution and bladder cancer mortality. The adjusted odds ratios (95% confidence interval) were 1.37 (1.03-1.82) for the group with medium air pollution level and 1.98 (1.36-2.88) for the group with high air pollution level when compared to the group with the low air pollution level. Trend analyses showed statistically significant trend in risk of death from bladder cancer with increasing air pollution level. The findings of this study warrant further investigation of the role of air pollutants in the etiology of bladder cancer.
为了研究空气污染与膀胱癌死亡风险之间的关系，作者利用1995年至2005年台湾地区发生的死亡病例进行了一项匹配病例对照研究。所有符合条件的膀胱癌死亡数据均来自台湾省卫生厅人口统计处。对照组由死于癌症以外原因或与泌尿生殖系统问题相关疾病的人组成。对照组按性别、出生年份和死亡年份与病例进行配对。每个匹配的对照组是从每个病例的可能对照组中随机选择的。城市空气污染暴露的分类基于二氧化氮和二氧化硫的测量水平。本研究结果表明，空气污染水平与膀胱癌死亡率之间存在显著的正相关。与低空气污染水平组相比，中等空气污染水平组的调整优势比（95%置信区间）为1.37（1.03 - 1.82），高空气污染水平组为1.98（1.36 - 2.88）。趋势分析表明，随着空气污染水平的增加，膀胱癌死亡风险存在统计学上的显著趋势。本研究结果值得进一步探讨空气污染物在膀胱癌病因学中的作用。
