Miyano M, Kato Y, Otsuka T, Saeki N, Tokuda Y
Department of Dermatology, Tokyo Medical College.
Arerugi. 1991 Jun;40(6):611-9.
We have developed a device tentatively named Multi Skit (Mu), a simple allergen test device, in order to conduct the skin test safely, accurately and conveniently. The utility of this device was evaluated by determining how the results obtained by the intradermal test (In) and Mu were correlated with those obtained by IgE RAST (RA) in 65 AD patients. RA values concerning nine antigens were compared to results obtained by the In and Mu in terms of the positive and negative response coincidence rates, overall coincidence rates, and false-positive and false-negative response rates. The correlation between RA data obtained from the literature and the results of the scratch test (Sc) was also evaluated. The results of In and RAST values showed no correlation regardless of the food antigen used. Mu and RAST values showed correlation with respect to all 4 food antigens except soy-bean, resulting in overall coincidence rates of 66.2 to 87.7%, which were higher than those concerning the Sc. With respect to false-positive responses to environmental antigens, the rate obtained by Mu was higher than that by the Sc, but it was lower than that by the In. However, Mu was the most excellent test with respect to the other indices, i.e., positive and negative response coincidence rates, overall coincidence rates (73.9-89.2%) and false-negative responses. The mechanism of Mu makers it possible to minimize variations from one investigator to another, and the major drawback of all other skin tests. Mu is a safe and convenient screening skin test device which provides accurate and specific test results.
我们研发了一种暂名为Multi Skit（Mu）的设备，这是一种简单的过敏原检测设备，目的是安全、准确且便捷地进行皮肤测试。通过测定65例特应性皮炎（AD）患者皮内试验（In）和Mu的结果与IgE放射变应原吸附试验（RA）结果的相关性，来评估该设备的实用性。将9种抗原的RA值与In和Mu所获结果在阳性和阴性反应符合率、总符合率以及假阳性和假阴性反应率方面进行比较。还评估了从文献中获取的RA数据与划痕试验（Sc）结果之间的相关性。无论使用何种食物抗原，In和RAST值均未显示出相关性。Mu和RAST值在除大豆外的所有4种食物抗原方面显示出相关性，总符合率为66.2%至87.7%，高于Sc的总符合率。关于对环境抗原的假阳性反应，Mu所获比率高于Sc，但低于In。然而，就其他指标而言，即阳性和阴性反应符合率、总符合率（73.9% - 89.2%）以及假阴性反应，Mu是最出色的检测方法。Mu的机制使得能够最大程度减少不同研究者之间的差异，而这是所有其他皮肤测试的主要缺点。Mu是一种安全便捷的筛查皮肤测试设备，能提供准确且特异的测试结果。
