Hitman G A, McCarthy M I
Baillieres Clin Endocrinol Metab. 1991 Sep;5(3):455-76. doi: 10.1016/s0950-351x(05)80142-9.
It is probable that NIDDM has a multifactorial origin in which environmental factors hasten the progression of the disease in genetically predisposed individuals. The importance of the genetic contribution to NIDDM has been established by the study of certain inbred populations, the almost 100% concordance of disease in monozygotic twins and by familial clustering. However, progress in identifying specific genetic factors involved in NIDDM has been slow and no consistent evidence has emerged supporting a major aetiological role for any of the genes so far studied. This may be due in part to methodological problems encountered in the identification of such disease susceptibility genes.
非胰岛素依赖型糖尿病（NIDDM）可能有多种因素起源，其中环境因素会加速疾病在具有遗传易感性个体中的进展。通过对某些近交群体的研究、同卵双胞胎中几乎100%的疾病一致性以及家族聚集性，已经确定了遗传因素对NIDDM的重要性。然而，在确定参与NIDDM的特定遗传因素方面进展缓慢，并且尚未出现一致的证据支持迄今为止所研究的任何基因具有主要病因作用。这可能部分归因于在识别此类疾病易感基因时遇到的方法学问题。
