Kurhanewicz John, Vigneron Daniel B
University of California, San Francisco, San Francisco, CA 94158, USA.
Magn Reson Imaging Clin N Am. 2008 Nov;16(4):697-710, ix-x. doi: 10.1016/j.mric.2008.07.005.
Commercial MR imaging/magnetic resonance spectroscopic imaging (MRSI) packages for staging prostate cancer on 1.5-T MR scanners are now available. The technology is becoming mature enough to begin assessing its clinical utility in selecting, planning, and following prostate cancer therapy. Before therapy, 1.5-T MR imaging/MRSI has the potential to improve the local evaluation of prostate cancer presence and volume and has a significant incremental benefit in the prediction of pathologic stage when added to clinical nomograms. After therapy, two metabolic biomarkers of effective and ineffective therapy have been identified and are being validated with 10-year outcomes. Accuracy can be improved by performing MR imaging/MRSI at higher magnetic field strengths, using more sensitive hyperpolarized (13)C MRSI techniques and through the addition of other functional MR techniques.
现在已有用于在1.5-T磁共振成像仪上对前列腺癌进行分期的商用磁共振成像/磁共振波谱成像(MRSI)软件包。该技术已足够成熟,可开始评估其在前列腺癌治疗的选择、规划和随访中的临床效用。在治疗前,1.5-T磁共振成像/MRSI有潜力改善对前列腺癌存在情况和体积的局部评估,并且在添加到临床列线图时,对病理分期的预测有显著的增量益处。治疗后,已确定了有效和无效治疗的两种代谢生物标志物,并正在通过10年的结果进行验证。通过在更高磁场强度下进行磁共振成像/MRSI、使用更灵敏的超极化(13)C MRSI技术以及添加其他功能性磁共振技术,可以提高准确性。