Ragland John D, Cools Roshan, Frank Michael, Pizzagalli Diego A, Preston Alison, Ranganath Charan, Wagner Anthony D
Department of Psychiatry and Behavioral Sciences, University of California at Davis, Sacramento, CA 95817, USA.
Schizophr Bull. 2009 Jan;35(1):197-212. doi: 10.1093/schbul/sbn134. Epub 2008 Oct 16.
Long-term memory (LTM) is a multifactorial construct, composed of different stages of information processing and different cognitive operations that are mediated by distinct neural systems, some of which may be more responsible for the marked memory problems that limit the daily function of individuals with schizophrenia. From the outset of the CNTRICS initiative, this multidimensionality was appreciated, and an effort was made to identify the specific memory constructs and task paradigms that hold the most promise for immediate translational development. During the second CNTRICS meeting, the LTM group identified item encoding and retrieval and relational encoding and retrieval as key constructs. This article describes the process that the LTM group went through in the third and final CNTRICS meeting to select nominated tasks within the 2 LTM constructs and within a reinforcement learning construct that were judged most promising for immediate development. This discussion is followed by each nominating authors' description of their selected task paradigm, ending with some thoughts about future directions.
长期记忆（LTM）是一个多因素的概念，由信息处理的不同阶段和不同的认知操作组成，这些阶段和操作由不同的神经系统介导，其中一些神经系统可能对导致精神分裂症患者日常功能受限的明显记忆问题负有更大责任。从CNTRICS计划一开始，这种多维性就得到了认可，并努力确定对即时转化发展最有前景的特定记忆概念和任务范式。在第二次CNTRICS会议期间，长期记忆小组将项目编码与检索以及关系编码与检索确定为关键概念。本文描述了长期记忆小组在第三次也是最后一次CNTRICS会议上所经历的过程，即在两个长期记忆概念以及一个强化学习概念中选择被认为最有即时发展前景的提名任务。随后是每位提名作者对其所选任务范式的描述，最后是对未来方向的一些思考。
