Hydrie M Zafar Iqbal, Shera A Samad, Fawwad Asher, Basit Abdul, Hussain Akhtar
Department of International Health, Institute of General Practice and Community Medicine, Faculty of Medicine, University of Oslo, Norway.
Metab Syndr Relat Disord. 2009 Apr;7(2):119-24. doi: 10.1089/met.2008.0055.
The clustering of central obesity, dyslipidemia, hypertension, and hyperglycemia known as metabolic syndrome has been associated with a two- to three-fold increase in type 2 diabetes (T2DM) and cardiovascular disease (CVD). It is recognized that the features of the metabolic syndrome can be present 10 years preceding T2DM and CVD. The objective of our study was to determine the prevalence of metabolic syndrome in adults aged 25 years and older from an urban population of Karachi, Pakistan, according to the International Diabetes Federation (IDF) definition and modified Adult Treatment Panel III (ATP III) criteria. This study involved a survey conducted from July, 2004, to December, 2004, by generating a computerized random sample of households in Lyari Town using a geographical imaging system (GIS). Out of the 85,520 households, 532 households were randomly selected and 867 adults > or =25 years old consented to take part in the survey; 363 of these subjects gave blood samples. The prevalence of diabetes was 9.4%, whereas 5.6% had impaired fasting glucose (abnormal glucose tolerance 15%). The prevalence of metabolic syndrome according to the IDF definition and modified ATP III criteria was 34.8% and 49%, respectively. Inclusion of modified waist circumference and specific body mass index (BMI) cut offs for Asians may help predict metabolic syndrome at an early stage. High prevalence of metabolic syndrome was identified irrespective of the definition applied in this population. This may call for immediate action to halt the accelerating risk of diabetes and CVD that would lead to a possible unparalleled rise in the cost of health care and human suffering.
被称为代谢综合征的中心性肥胖、血脂异常、高血压和高血糖聚集现象，与2型糖尿病（T2DM）和心血管疾病（CVD）增加两到三倍有关。人们认识到，代谢综合征的特征可能在T2DM和CVD出现前10年就已存在。我们研究的目的是根据国际糖尿病联盟（IDF）的定义和修改后的成人治疗小组第三次报告（ATP III）标准，确定巴基斯坦卡拉奇城市25岁及以上成年人中代谢综合征的患病率。本研究涉及2004年7月至12月进行的一项调查，通过地理成像系统（GIS）在利亚里镇生成家庭的计算机随机样本。在85520个家庭中，随机选择了532个家庭，867名年龄≥25岁的成年人同意参与调查；其中363名受试者提供了血样。糖尿病患病率为9.4%，而空腹血糖受损（葡萄糖耐量异常15%）的患病率为5.6%。根据IDF定义和修改后的ATP III标准，代谢综合征的患病率分别为34.8%和49%。纳入针对亚洲人的修改后的腰围和特定体重指数（BMI）临界值可能有助于早期预测代谢综合征。无论采用何种定义，该人群中代谢综合征的患病率都很高。这可能需要立即采取行动，以遏制糖尿病和CVD风险的加速上升，否则可能导致医疗保健成本和人类痛苦出现前所未有的增长。
