Bedaiwy Mohamed A, Shahin Ahmed Y, Falcone Tommaso
Department of Obstetrics-Gynecology, The Cleveland Clinic Foundation, Cleveland, Ohio44195, USA.
Fertil Steril. 2008 Dec;90(6):2031-55. doi: 10.1016/j.fertnstert.2008.08.009. Epub 2008 Oct 18.
To review the advances and controversies in the field of reproductive organ transplantation.
RESULT(S): Although many cancer treatments can damage female reproductive organs, leading to temporary or permanent infertility, recent advances in cancer management have translated into improved patient survival, making preservation of reproductive function a more important priority than ever before. Reproductive organ transplantation represents a new potential treatment for patients facing infertility as a result of cancer treatment. Pregnancies have now been reported from several centers after transplanting fresh and frozen ovarian tissue pieces. The longevity of the graft and its potential long-term complications are unknown. However, it seems clear that the ovarian tissue graft has a shortened life span. Allogeneic reproductive organ transplants are under investigation. Patients must take immunosuppressive medications following heterologus transplantation, and these medications can cause adverse side effects. The effects on the fetus are largely unknown.
CONCLUSION(S): Despite the recent biologic and clinical advances, reproductive organ transplantation remains experimental and controversial.
综述生殖器官移植领域的进展与争议。
尽管许多癌症治疗方法会损害女性生殖器官，导致暂时或永久性不孕，但癌症治疗方面的最新进展已使患者生存率提高，这使得保留生殖功能比以往任何时候都更为重要。生殖器官移植为因癌症治疗而面临不孕的患者提供了一种新的潜在治疗方法。目前已有多个中心报道了新鲜和冷冻卵巢组织片移植后成功妊娠的案例。移植物的寿命及其潜在的长期并发症尚不清楚。然而，卵巢组织移植物的寿命似乎明显缩短。同种异体生殖器官移植正在研究中。患者在异种移植后必须服用免疫抑制药物，而这些药物可能会引起不良副作用。对胎儿的影响大多未知。
尽管最近在生物学和临床方面取得了进展，但生殖器官移植仍处于实验阶段且存在争议。
