Hilgers A, Krueger G R, Lembke U, Ramon A
International Institute of Immunopathology, Inc. Cologne, Washington, DC.
In Vivo. 1991 May-Jun;5(3):201-5.
Thirty-five patients with chronic fatigue syndrome according to the criteria of Holmes were followed for periods of up to eight years. The most frequent symptoms were severe fatigue, arthralgias and myalgias, recurrent oropharyngitis and various psychiatric disorders. More than half of the patients suffered from neuropathy, lymphadenopathy, gastrointestinal complaints and recurrent low-grade fever. Recurrent or persistent activity of human herpesvirus -6 infection was seen in 73% of the patients and of Epstein-Barr virus in 34.4%. In addition, various other infections were diagnosed at lower frequency. Initial routine immunologic screening revealed various types of deficiencies, these were yet inconsistent and variable when different patients were compared with each other. Tentative treatments included in immunoglobulins, nonspecific immunostimulation and virostatic drugs. No consistently positive results were obtained with any treatment schedule although immunoglobulins appeared the most efficient measure. In addition, psychologic care of the patients is indicated, since disturbances in the psycho-neuroimmunologic regulation may play a significant role in the pathogenesis of the disease.
按照霍姆斯标准确诊的35例慢性疲劳综合征患者接受了长达8年的随访。最常见的症状为严重疲劳、关节痛和肌痛、复发性口咽炎以及各种精神障碍。超过半数的患者患有神经病变、淋巴结病、胃肠道不适以及反复低热。73%的患者出现人疱疹病毒6型感染反复或持续活动，34.4%的患者出现EB病毒感染反复或持续活动。此外，还诊断出其他各种感染，但发生率较低。初始常规免疫筛查发现了各种类型的缺陷，不同患者之间这些缺陷并不一致且存在差异。试验性治疗包括使用免疫球蛋白、非特异性免疫刺激和抗病毒药物。尽管免疫球蛋白似乎是最有效的措施，但任何治疗方案均未取得持续的阳性结果。此外，由于心理神经免疫调节紊乱可能在该病的发病机制中起重要作用，因此对患者进行心理护理是必要的。
