Dhanasekaran D N, Reddy E P
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Oncogene. 2008 Oct 20;27(48):6245-51. doi: 10.1038/onc.2008.301.
Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and antiapoptotic proteins through distinct phosphorylation events. This review analyses our present understanding of the role of JNK in apoptotic signaling and the various mechanisms by which JNK promotes apoptosis.
Jun氨基末端激酶（JNK）在死亡受体启动的外源性以及线粒体介导的内源性凋亡途径中发挥关键作用。JNK通过特定转录因子的反式激活上调促凋亡基因，从而激活凋亡信号，或者通过不同的磷酸化事件直接调节线粒体促凋亡蛋白和抗凋亡蛋白的活性。这篇综述分析了我们目前对JNK在凋亡信号传导中的作用以及JNK促进凋亡的各种机制的理解。
