Klimshina O A, Erin A N
Biull Eksp Biol Med. 1991 Jun;111(6):607-8.
It was shown by the methods of luminol- and lucigenin-dependent chemiluminescence that 6-hydroxydopamine 6-ONDA autooxidation is accompanied by generation of superoxide anion-radical which can further react with next 6-ONDA molecule. This fact is based on the observations that intensities of luminol- and lucigenin-dependent chemiluminescence during 6-ONDA autooxidation was increased in aprotonic aqueous solutions (with the decreasing of pH) and was extremely depended on 6-ONDA concentration. The obtained data allows to suggest that one of the possible mechanisms of 6-ONDA neurotoxic action includes the generation of superoxide, whose dismutation to hydrogen peroxide in the presence of transient valency ions gives rise to HO.
通过鲁米诺和光泽精依赖的化学发光方法表明，6-羟基多巴胺（6-ONDA）的自氧化伴随着超氧阴离子自由基的产生，该自由基可进一步与下一个6-ONDA分子反应。这一事实基于以下观察结果：在非质子水溶液中（随着pH值降低），6-ONDA自氧化过程中鲁米诺和光泽精依赖的化学发光强度增加，并且极度依赖于6-ONDA浓度。所获得的数据表明，6-ONDA神经毒性作用的一种可能机制包括超氧的产生，在存在变价离子的情况下，超氧歧化为过氧化氢会产生羟基自由基（HO）。
