Neugut A I, Murray T I, Garbowski G C, Forde K A, Treat M R, Waye J D, Fenoglio-Preiser C
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Cancer. 1991 Oct 1;68(7):1644-7. doi: 10.1002/1097-0142(19911001)68:7<1644::aid-cncr2820680730>3.0.co;2-k.
Multiple studies have suggested a possible relationship between prior cholecystectomy and the occurrence of subsequent colorectal carcinoma. This relationship has been particularly noticed among female patients and for right-sided lesions of the colon. In the current study, the authors undertook a case-control study among patients who underwent colonoscopy in three private practices in New York City between April 1986 and March 1988. Over this period, 302 adenomatous polyp cases, 106 colon cancer cases, and 507 controls were interviewed regarding their prior history of cholecystectomy. Overall, no significant association was observed between cholecystectomy and either colorectal adenomatous polyps or cancer. Cholecystectomy does not appear to be a significant risk factor for colorectal neoplasia.
多项研究表明，既往胆囊切除术与随后发生的结直肠癌之间可能存在关联。这种关联在女性患者以及结肠右侧病变中尤为明显。在本研究中，作者对1986年4月至1988年3月期间在纽约市三家私人诊所接受结肠镜检查的患者进行了一项病例对照研究。在此期间，对302例腺瘤性息肉病例、106例结肠癌病例和507名对照者就其既往胆囊切除术病史进行了访谈。总体而言，未观察到胆囊切除术与结直肠腺瘤性息肉或癌症之间存在显著关联。胆囊切除术似乎不是结直肠肿瘤形成的重要危险因素。
