Hakala T, Mecklin J P, Forss M, Järvinen H, Lehtovirta P
Department of Obstetrics and Gynecology of Helsinki University Central Hospital, Finland.
Cancer. 1991 Oct 1;68(7):1656-9. doi: 10.1002/1097-0142(19911001)68:7<1656::aid-cncr2820680732>3.0.co;2-7.
The study group consisted of 26 women with endometrial adenocarcinoma belonging to 19 cancer families. Age at the onset of cancer, the stage and histologic differentiation of the tumor, initial symptoms, other malignancies, 5-year survival, and transmission of cancer to descendants were studied. The focus was on the importance of endometrial carcinoma in the tumor spectrum. The diagnosis of cancer family was delayed in 14 of the 19 families because endometrial carcinoma was not included in the primary diagnostic carcinoma. This delay may have been harmful to 16 family members who had carcinomas later in life. In ten of the 14 women with multiple malignancies, endometrial adenocarcinoma was the primary malignancy diagnosed, thus enabling the suspicion of a gene carrier and screening for subsequent malignancies. The authors concluded that endometrial carcinoma is a significant component of cancer family syndrome and should be included in the main criteria of Lynch syndrome II.
研究组由来自19个癌症家族的26例子宫内膜腺癌女性组成。对癌症发病年龄、肿瘤分期和组织学分化、初始症状、其他恶性肿瘤、5年生存率以及癌症向后代的传递情况进行了研究。重点在于子宫内膜癌在肿瘤谱中的重要性。19个家族中有14个家族的癌症家族诊断被延迟，原因是原发性诊断癌中未包括子宫内膜癌。这种延迟可能对16名后来患癌的家庭成员有害。在14例患有多种恶性肿瘤的女性中，有10例的原发性恶性肿瘤诊断为子宫内膜腺癌，从而得以怀疑基因携带者并对后续恶性肿瘤进行筛查。作者得出结论，子宫内膜癌是癌症家族综合征的重要组成部分，应纳入林奇综合征II的主要标准。
