Cohen B B, Porter D E, Wallace M R, Carothers A, Steel C M
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.
Am J Hum Genet. 1993 Apr;52(4):723-9.
DNA from members of 15 pedigrees each containing between three and eight cases of breast cancer have been collected from southeastern Scotland. Polymorphic markers on chromosome 17q were screened to locate a putative breast cancer gene by using DNA from relevant individuals within these families. Pairwise LOD scores were calculated for markers D17S74, NM23, D17S588, and D17S579. The maximal summated LOD for the 15 families was 5.44 at theta = .034, when D17S588 (42D6) was used. In these breast cancer families, a subset which did not give evidence for linkage to this region could be identified.
已从苏格兰东南部收集了15个家系成员的DNA，每个家系中有3至8例乳腺癌病例。通过使用这些家族中相关个体的DNA，对17号染色体q上的多态性标记进行筛选，以定位一个假定的乳腺癌基因。计算了标记D17S74、NM23、D17S588和D17S579的成对LOD分数。当使用D17S588（42D6）时，15个家系的最大累计LOD在θ=0.034时为5.44。在这些乳腺癌家族中，可以识别出一个未提供与该区域连锁证据的子集。
