健康受试者和慢性甲状腺炎患者血清中的抗甲状腺过氧化物酶抗体：抑制甲状腺过氧化物酶活性能力的差异。
Anti-thyroid peroxidase antibodies in sera from healthy subjects and from patients with chronic thyroiditis: differences in the ability to inhibit thyroid peroxidase activities.
作者信息
Kohno Y, Yamaguchi F, Saito K, Niimi H, Nishikawa T, Hosoya T
机构信息
Department of Pediatrics, School of Medicine, Chiba University, Japan.
出版信息
Clin Exp Immunol. 1991 Sep;85(3):459-63. doi: 10.1111/j.1365-2249.1991.tb05749.x.
Abstract
A significant percentage (6.4%) of healthy subjects was found to contain anti-thyroid peroxidase (TPO) antibodies in their sera. However, in contrast with IgG from sera of patients with chronic thyroiditis, IgG from sera of healthy subjects did not inhibit TPO activities both in guaiacol and iodide assays. In addition, anti-TPO antibodies from healthy subjects did not block the inhibition of enzyme activities by anti-TPO antibodies from patients. These findings suggest that anti-TPO antibodies from healthy subjects do not bind to the epitopes relating to substrate-combining sites of TPO. Thus, the specificities of anti-TPO antibodies in healthy subjects may differ from those in cases of chronic thyroiditis.
摘要
发现相当比例（6.4%）的健康受试者血清中含有抗甲状腺过氧化物酶（TPO）抗体。然而，与慢性甲状腺炎患者血清中的IgG不同，健康受试者血清中的IgG在愈创木酚和碘化物检测中均未抑制TPO活性。此外，健康受试者的抗TPO抗体不会阻断患者抗TPO抗体对酶活性的抑制作用。这些发现表明，健康受试者的抗TPO抗体不与TPO底物结合位点相关的表位结合。因此，健康受试者中抗TPO抗体的特异性可能与慢性甲状腺炎患者不同。
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