Coloe Dosal Jacquelyn, Stewart Paul W, Lin Ja-An, Williams Christianna S, Morrell Dean S
Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FloridaDepartment of Dermatology, University of North Carolina, Chapel Hill, North CarolinaDepartment of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.
Pediatr Dermatol. 2014 Jul-Aug;31(4):440-9. doi: 10.1111/j.1525-1470.2012.01810.x. Epub 2012 Aug 16.
Our aim was to study the effects and safety of cantharidin in the treatment of molluscum contagiosum (MC), we conducted a prospective, double-blinded, placebo-controlled, randomized clinical trial to evaluate the safety and efficacy of topical cantharidin for treatment of pediatric MC in an academic ambulatory care center. Twenty-nine children aged 5-10 with a diagnosis of MC were enrolled to receive treatment with cantharidin or placebo. The main outcome measure was complete clearance of all molluscum lesions. In contrast to previous retrospective observational studies, the performance of cantharidin treatment over 2 months was not substantially better than the performance of placebo. The scope of follow-up was limited to five visits over 2 months of treatment. A longer follow-up period might have captured a greater effect of cantharidin. Over a 2 month period, the magnitude of the cantharidin treatment effects in the target population are, at best, not large. This study provided objective unbiased estimates of the magnitude of cantharidin treatment effects and provided important prospective safety data. Our subjects experienced minimal side effects when treated with cantharidin.
我们的目的是研究斑蝥素治疗传染性软疣（MC）的效果及安全性，我们在一家学术门诊护理中心开展了一项前瞻性、双盲、安慰剂对照、随机临床试验，以评估外用斑蝥素治疗儿童MC的安全性和有效性。29名年龄在5至10岁、诊断为MC的儿童被纳入研究，接受斑蝥素或安慰剂治疗。主要结局指标是所有软疣皮损完全清除。与之前的回顾性观察研究不同，斑蝥素治疗2个月的效果并不比安慰剂显著更好。随访范围限于治疗的2个月内进行5次就诊。更长的随访期可能会发现斑蝥素的更大效果。在2个月的时间里，斑蝥素对目标人群的治疗效果充其量不大。本研究提供了斑蝥素治疗效果大小的客观、无偏估计，并提供了重要的前瞻性安全性数据。我们的受试者在接受斑蝥素治疗时出现的副作用极小。
