He Zhaoping, O'Reilly Robert C, Mehta Devendra
Division of Pediatric Otolaryngology, Alfred I. duPont Hospital for Children, Wilmington, DE 19899, USA.
Curr Allergy Asthma Rep. 2008 Nov;8(6):513-8. doi: 10.1007/s11882-008-0094-7.
Gastroesophageal reflux and extraesophageal reflux have been postulated to be involved in the pathogenesis of otitis media. This is supported by recent studies revealing the presence of gastric pepsin in the middle ear space of children with otitis media but not in control patients without otitis media. Reflux's role in otitis media appears to be most pronounced in younger children and those with purulent effusions.
胃食管反流和食管外反流被认为与中耳炎的发病机制有关。最近的研究支持了这一观点，这些研究发现，在患有中耳炎的儿童中耳腔中存在胃蛋白酶，而在没有中耳炎的对照患者中则不存在。反流在中耳炎中的作用在年幼儿童和有脓性积液的儿童中似乎最为明显。
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