Nilsson Birgitta Blakstad, Westheim Arne, Risberg May Arna
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway.
Am J Cardiol. 2008 Nov 1;102(9):1220-4. doi: 10.1016/j.amjcard.2008.06.046. Epub 2008 Aug 29.
Studies on the long-term effects of exercise training programs on functional capacity and the quality of life in patients with chronic heart failure (CHF) are sparse. The aim of this study was to evaluate the long-term effects of group-based, high-intensity interval training on functional capacity and the quality of life in 80 patients with stable CHF (mean age 70.1 +/- 7.9 years) in New York Heart Association classes II to IIIB. Patients were randomized to either an exercise group (n = 40) or a control group (n = 40). The mean ejection fractions at baseline were 31 +/- 8% in the exercise group and 31 +/- 1% in the control group. The exercise group exercised twice a week for 4 months in addition to 4 consultations with a CHF nurse. Six-minute walking distance, workload and exercise time on a cycle ergometer test, and the quality of life were measured at baseline and 4 and 12 months after enrollment. After 4 months, functional capacity (6-minute walking distance +58 vs -15 m, p <0.001) and the quality of life (Minnesota Living With Heart Failure Questionnaire score +10 vs -1 point, p <0.005) improved significantly in the exercise group compared with the control group. After 12 months, the improvements were still significant in the exercise group compared with the control group for all parameters (6-minute walking distance +41 vs -20 m, p <0.001; workload +10 vs -1 W, p = 0.001; exercise time +53 vs -6 seconds, p = 0.003; quality of life +10 vs -6 points, p = 0.003). In conclusion, the results support the implementation of a group-based aerobic interval training program to improve long-term effects on functional capacity and the quality of life in patients with CHF.
关于运动训练计划对慢性心力衰竭（CHF）患者功能能力和生活质量的长期影响的研究较少。本研究的目的是评估基于小组的高强度间歇训练对纽约心脏协会II至IIIB级80例稳定CHF患者（平均年龄70.1±7.9岁）的功能能力和生活质量的长期影响。患者被随机分为运动组（n = 40）或对照组（n = 40）。运动组和对照组基线时的平均射血分数分别为31±8%和31±1%。运动组除了与CHF护士进行4次咨询外，每周锻炼两次，持续4个月。在基线以及入组后4个月和12个月测量6分钟步行距离、自行车测力计测试中的工作量和运动时间以及生活质量。4个月后，与对照组相比，运动组的功能能力（6分钟步行距离增加58米 vs 减少15米，p<0.001）和生活质量（明尼苏达心力衰竭生活问卷评分增加10分 vs 减少1分，p<0.005）显著改善。12个月后，运动组与对照组相比，所有参数的改善仍然显著（6分钟步行距离增加41米 vs 减少20米，p<0.001；工作量增加10瓦 vs 减少1瓦，p = 0.001；运动时间增加53秒 vs 减少6秒，p = 0.003；生活质量增加10分 vs 减少6分，p = 0.003）。总之，结果支持实施基于小组的有氧间歇训练计划，以改善对CHF患者功能能力和生活质量的长期影响。
