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Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation and reformation in the rat model.

作者信息

Urman B, Gomel V

机构信息

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.

出版信息

Fertil Steril. 1991 Sep;56(3):568-70. doi: 10.1016/s0015-0282(16)54559-2.

DOI:10.1016/s0015-0282(16)54559-2
PMID:1894038
Abstract

The local application of 0.25% or 0.4% HA before the induction of a measured laser injury on the rat uterine horn was associated with a significant reduction (P less than 0.05) in postoperative IP adhesions when compared with the group of animals pretreated with the diluent vehicle PBS or received no pretreatment. However, 0.4% HA, when applied in a similar manner, was ineffective in reducing reformation of adhesions after microsurgical adhesiolysis.

摘要

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Application of hyaluronic acid/sodium alginate-based microparticles to prevent tissue adhesion in a rabbit model.
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