Hung Po-Cheng, Wang Huei-Shyong, Chou Ming-Liang, Wong Alex M-C
Division of Pediatric Neurology, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Pediatr Neurol. 2008 Nov;39(5):365-7. doi: 10.1016/j.pediatrneurol.2008.07.026.
Tuberous sclerosis complex is a protean, genetically determined disease that may involve any organ or tissue and lead to a great number of signs and clinical features. Occlusive vascular disease and aneurysms of the cerebral and visceral arteries were described in these patients. We report on an 8-month-old boy who manifested tuberous sclerosis complex with multiple intracranial aneurysms involving the internal carotid artery and middle cerebral artery. The unusual features of our case favor the concepts of the presence of an arterial dysplasia in tuberous sclerosis complex, and of developmental defects as the cause of intracranial aneurysms.
结节性硬化症是一种具有多种表现、由基因决定的疾病，可累及任何器官或组织，并导致大量体征和临床特征。这些患者中曾描述过闭塞性血管疾病以及脑动脉和内脏动脉的动脉瘤。我们报告了一名8个月大的男孩，他表现出结节性硬化症，伴有多个累及颈内动脉和大脑中动脉的颅内动脉瘤。我们病例的不寻常特征支持结节性硬化症中存在动脉发育异常以及发育缺陷是颅内动脉瘤病因的观点。
