Yokum Dawn, Glass Georgina, Cheung Ching Fun, Cunningham John, Fan Stanley, Madden Angela M
Department of Health and Human Sciences, Barts and the London NHS Trust, London Metropolitan University, London, UK.
J Ren Nutr. 2008 Nov;18(6):521-9. doi: 10.1053/j.jrn.2008.05.003.
To evaluate the effectiveness of a protocol designed to optimize serum phosphate levels in patients undergoing regular hemodialysis (HD).
Randomized, controlled trial.
Hemodialysis units at Barts and the London NHS Trust and satellite units.
Thirty-four clinically stable adults undergoing regular HD with a serum phosphate level >1.8 mmol/L on at least one occasion within 4 months of starting the study.
Management of serum phosphate using a specially designed phosphate management protocol during a 4-month study period implemented by a renal dietitian and renal pharmacist compared with standard practice.
Change in serum phosphate levels in both groups after 4 months.
Patients managed using the phosphate management protocol had a significantly greater reduction in serum phosphate levels compared with patients receiving standard practice (-0.22 +/- 0.67 mmol/L vs. +0.19 +/- 0.32 mmol/L, P = 0.03).
The phosphate management protocol was effective, and its implementation was associated with significantly better serum phosphate control in patients undergoing regular HD.
评估一项旨在优化接受定期血液透析（HD）患者血清磷酸盐水平的方案的有效性。
随机对照试验。
巴茨和伦敦国民保健服务信托基金的血液透析单位及卫星单位。
34名临床稳定的成年人，在开始研究的4个月内至少有一次血清磷酸盐水平>1.8 mmol/L，接受定期HD治疗。
在为期4个月的研究期间，由肾脏营养师和肾脏药剂师采用专门设计的磷酸盐管理方案管理血清磷酸盐，与标准治疗方法进行比较。
4个月后两组血清磷酸盐水平的变化。
与接受标准治疗的患者相比，采用磷酸盐管理方案治疗的患者血清磷酸盐水平显著降低（-0.22±0.67 mmol/L对+0.19±0.32 mmol/L，P = 0.03）。
磷酸盐管理方案有效，其实施与接受定期HD治疗的患者血清磷酸盐控制显著改善相关。
