Watts R L, Mandir A S, Ahn K J, Juncos J L, Zakers G O, Freeman A
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia.
Geriatrics. 1991 Aug;46 Suppl 1:31-6.
We have been interested in the application of quantitative measures of motor performance as a possible means of early detection of Parkinson's disease. To assess motor function, we have measured movement time (the physiologic correlate of bradykinesia) and reaction time (simple and directional choice) with an upper limb motor task, and tremor with accelerometry and electromyographic recordings. In this report we describe preliminary data from a Parkinson's disease patient group with symptoms of fewer than 2 years' average duration (compared with an age- and gender-matched normal control group) which indicate that precise, quantitative tests of motor function can detect the slight deviations from normal that are present in early Parkinson's disease. It appears that tests of bradykinesia are most sensitive, and detection of rest tremor is most specific. These tests may be applicable in screening individuals who are suspected of having or are "at risk for" Parkinson's disease and other related disorders.
我们一直对应用运动表现的定量测量方法作为早期检测帕金森病的一种可能手段感兴趣。为了评估运动功能，我们使用上肢运动任务测量了运动时间（运动迟缓的生理相关指标）和反应时间（简单反应和定向选择反应），并通过加速度测量和肌电图记录来测量震颤。在本报告中，我们描述了一组帕金森病患者的初步数据，这些患者的症状平均持续时间不到2年（与年龄和性别匹配的正常对照组相比），这些数据表明，精确的运动功能定量测试可以检测出早期帕金森病中存在的与正常情况的细微偏差。似乎运动迟缓测试最为敏感，而静止性震颤的检测最为特异。这些测试可能适用于筛查疑似患有帕金森病或“有患帕金森病风险”的个体以及其他相关疾病。
