Watts R L, Mandir A S, Ahn K J, Juncos J L, Zakers G O, Freeman A
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322.
Neurology. 1991 May;41(5 Suppl 2):44-8; discussion 48-9. doi: 10.1212/wnl.41.5_suppl_2.44.
We have been interested in the application of quantitative measures of motor performance as a possible means of early detection of Parkinson's disease. To assess motor function, we have measured movement time (the physiologic correlate of bradykinesia) and reaction time (simple and directional choice) with an upper limb motor task, and tremor with accelerometry and electromyographic recordings. In this report we describe preliminary data from a Parkinson's disease patient group with symptoms of fewer than 2 years' average duration (compared with an age- and gender-matched normal control group) which indicate that precise, quantitative tests of motor function can detect the slight deviations from normal that are present in early Parkinson's disease. It appears that tests of bradykinesia are most sensitive, and detection of rest tremor is most specific. These tests may be applicable in screening individuals who are suspected of having or are "at risk for" Parkinson's disease and other related disorders.
我们一直对运动表现的定量测量作为早期检测帕金森病的一种可能手段的应用感兴趣。为了评估运动功能，我们通过上肢运动任务测量了运动时间（运动迟缓的生理相关指标）和反应时间（简单反应和定向选择反应），并通过加速度测量和肌电图记录测量了震颤。在本报告中，我们描述了来自平均病程少于2年的帕金森病患者组的初步数据（与年龄和性别匹配的正常对照组相比），这些数据表明，精确的运动功能定量测试可以检测出早期帕金森病中存在的与正常情况的细微偏差。似乎运动迟缓测试最为敏感，而静止性震颤的检测最为特异。这些测试可能适用于筛查疑似患有帕金森病或“有风险患”帕金森病及其他相关疾病的个体。
