Stranges Saverio, Dorn Joan M, Shipley Martin J, Kandala Ngianga-Bakwin, Trevisan Maurizio, Miller Michelle A, Donahue Richard P, Hovey Kathleen M, Ferrie Jane E, Marmot Michael G, Cappuccio Francesco P
Cardiovascular Medicine and Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, University Hospital-Warwickshire and Coventry Campus, Clifford Bridge Road, Coventry, United Kingdom.
Am J Epidemiol. 2008 Dec 15;168(12):1353-64. doi: 10.1093/aje/kwn337. Epub 2008 Oct 22.
The authors examined sociodemographic, lifestyle, and comorbidity factors that could confound or mediate U-shaped associations between sleep duration and health in 6,472 United Kingdom adults from the Whitehall II Study (1997-1999) and 3,027 US adults from the Western New York Health Study (1996-2001). Cross-sectional associations between short (<6 hours) and long (>8 hours) durations of sleep across several correlates were calculated as multivariable odds ratios. For short sleep duration, there were significant, consistent associations in both samples for unmarried status (United Kingdom: adjusted odds ratio (AOR) = 1.49, 95% confidence interval (CI): 1.15, 1.94; United States: AOR = 1.49, 95% CI: 1.10, 2.02), body mass index (AORs were 1.04 (95% CI: 1.01, 1.07) and 1.02 (95% CI: 1.00, 1.05)), and Short Form-36 physical (AORs were 0.96 (95% CI: 0.95, 0.98) and 0.97 (95% CI: 0.96, 0.98)) and mental (AORs were 0.95 (95% CI: 0.94, 0.96) and 0.98 (95% CI: 0.96, 0.99)) scores. For long sleep duration, there were fewer significant associations: age among men (AORs were 1.08 (95% CI: 1.01, 1.14) and 1.05 (95% CI: 1.02, 1.08)), low physical activity (AORs were 1.75 (95% CI: 0.97, 3.14) and 1.60 (95% CI: 1.09, 2.34)), and Short Form-36 physical score (AORs were 0.96 (95% CI: 0.93, 0.99) and 0.97 (95% CI: 0.95, 0.99)). Being unmarried, being overweight, and having poor general health are associated with short sleep and may contribute to observed disease associations. Long sleep may represent an epiphenomenon of comorbidity.
作者在来自白厅II研究（1997 - 1999年）的6472名英国成年人以及来自纽约西部健康研究（1996 - 2001年）的3027名美国成年人中，研究了可能混淆或介导睡眠时间与健康之间U型关联的社会人口统计学、生活方式和合并症因素。计算了在几个相关因素中，短睡眠（<6小时）和长睡眠（>8小时）持续时间之间的横断面关联，以多变量优势比表示。对于短睡眠时间，在两个样本中，未婚状态（英国：调整后优势比（AOR）= 1.49，95%置信区间（CI）：1.15，1.94；美国：AOR = 1.49，95% CI：1.10，2.02）、体重指数（AOR分别为1.04（95% CI：1.01，1.07）和1.02（95% CI：1.00，1.05））以及简短健康调查问卷36项身体（AOR分别为0.96（95% CI：0.95，0.98）和0.97（95% CI：0.96，0.98））和精神（AOR分别为0.95（95% CI：0.94，0.96）和0.98（95% CI：0.96，0.99））评分方面，存在显著且一致的关联。对于长睡眠时间，显著关联较少：男性中的年龄（AOR分别为1.08（95% CI：1.01，1.14）和1.05（95% CI：1.02，1.08））、低身体活动水平（AOR分别为1.75（95% CI：0.97，3.14）和1.60（95% CI：1.09，2.34））以及简短健康调查问卷36项身体评分（AOR分别为0.96（95% CI：0.93，0.99）和0.97（95% CI：0.95，0.
