Pietschmann Peter, Rauner Martina, Sipos Wolfgang, Kerschan-Schindl Katharina
Department of Pathophysiology, Center for Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria.
Gerontology. 2009;55(1):3-12. doi: 10.1159/000166209. Epub 2008 Oct 24.
Osteoporosis, a classical age-related disease and known to be more common in women than in men, has been reported increasingly often in men during the past few years. Although men at all ages after puberty have larger bones than women, resulting in greater bending strength, mortality after a hip fracture, one of the major complications of osteoporosis, is more common in men than in women. Sex hormone deficiency is associated with unrestrained osteoclast activity and bone loss. Even though estrogen deficiency is more pronounced in women, it appears to be a major factor in the pathogenesis of osteoporosis in both genders. In contrast to osteoporosis in postmenopausal women, the treatment of osteoporosis in men has been scarcely reported. Nevertheless, some drugs commonly used for the treatment of osteoporosis in women also appear to be effective in men. The aim of this study is to review primary osteoporosis in the elderly with particular emphasis on gender-related aspects.
骨质疏松症是一种典型的与年龄相关的疾病，已知在女性中比在男性中更为常见，但在过去几年中，男性中该疾病的报道越来越多。尽管青春期后的所有年龄段男性的骨骼都比女性大，从而具有更大的抗弯强度，但骨质疏松症的主要并发症之一——髋部骨折后的死亡率，在男性中比在女性中更为常见。性激素缺乏与破骨细胞活动不受抑制和骨质流失有关。尽管雌激素缺乏在女性中更为明显，但它似乎是两性骨质疏松症发病机制中的一个主要因素。与绝经后女性的骨质疏松症不同，男性骨质疏松症的治疗鲜有报道。然而，一些常用于治疗女性骨质疏松症的药物在男性中似乎也有效。本研究的目的是回顾老年人原发性骨质疏松症，特别强调与性别相关的方面。
