Sugerman S B, Mobarhan S, Bowen P E, Stacewicz-Sapuntzakis M, Langenberg P, Henderson C, Kiani R, Friedman H, Lucchesi D
Department of Medicine, School of Public Health, University of Illinois, Chicago.
J Am Coll Nutr. 1991 Aug;10(4):297-307. doi: 10.1080/07315724.1991.10718156.
The present study was designed to evaluate age-related differences in serum beta-carotene time curve response characteristics when a beta-carotene dose was given in conjunction with 1500 kcal over the course of a day. On two consecutive days, seven old (73 +/- 4 years) and six young (24 +/- 1 years) men were each fed three 500-kcal meals of an isotonic liquid formula diet containing only trace amounts of beta-carotene. On the first day of testing, no supplemental beta-carotene was given (baseline day). A 15 mg dose of beta-carotene was fed with the morning meal on the second day (test dose day). Fasting blood and hourly blood samples were obtained for 8 consecutive hours on both days. Additional blood was drawn 24 and 48 hours after the test beta-carotene dose. There were no statistical differences in baseline beta-carotene concentrations between the two age groups tested, but, because of high individual variability, serum time curve characteristics were adjusted for fasting beta-carotene levels. After adjustment, the postdose serum beta-carotene response was two to three times greater (p less than or equal to 0.04) in young subjects, as evaluated by peak concentration, area under the curve, or ascending slope of the serum response curve. Examination of factors besides age group that may have accounted for these results suggests that the serum response of the elderly may be more a function of body composition and/or serum lipid patterns than of age per se. However, in the present US population, it may not be valid to control for these factors, which are both closely related to aging.
本研究旨在评估当一天内给予β-胡萝卜素剂量并搭配1500千卡热量时，血清β-胡萝卜素时间曲线反应特征的年龄相关差异。在连续两天里，七名老年男性（73±4岁）和六名年轻男性（24±1岁）分别食用了三份500千卡的等渗液体配方饮食餐，每份餐仅含微量β-胡萝卜素。在测试的第一天，未给予补充β-胡萝卜素（基线日）。在第二天（测试剂量日），早餐时给予15毫克剂量的β-胡萝卜素。两天均连续8小时采集空腹血和每小时一次的血样。在给予测试剂量的β-胡萝卜素后24小时和48小时采集额外血样。两个受试年龄组的基线β-胡萝卜素浓度无统计学差异，但由于个体差异较大，血清时间曲线特征根据空腹β-胡萝卜素水平进行了调整。调整后，通过峰值浓度、曲线下面积或血清反应曲线的上升斜率评估，年轻受试者给药后血清β-胡萝卜素反应高出两到三倍（p≤0.04）。对可能导致这些结果的年龄组以外的因素进行检查表明，老年人的血清反应可能更多地取决于身体成分和/或血清脂质模式，而非年龄本身。然而，在美国当前人群中，控制这些与衰老密切相关的因素可能并不有效。
