Adami Silvano, Gatti Davide, Viapiana Ombretta, Fiore Carmelo Erio, Nuti Ranuccio, Luisetto Giovanni, Ponte Marco, Rossini Maurizio
Rheumatology Unit, Ospedale di Valeggio, University of Verona, 37067, Valeggio, Verona, Italy.
Calcif Tissue Int. 2008 Dec;83(6):388-92. doi: 10.1007/s00223-008-9184-8. Epub 2008 Oct 24.
Strenuous physical activity in young individuals has an important effect on both bone mass and bone turnover but the effect of moderate physical activity in adults remains uncertain. In a large cohort (N = 530) of healthy premenopausal women, bone formation markers (osteocalcin and N-terminal propeptide of type 1 procollagen [P1NP]), but not serum C-telopeptide of type 1 collagen (sCTX), were found to be significantly associated with the level of physical activity, and this association remained significant after adjusting the data (ANCOVA) by age and body mass index. Mean spine and hip bone mineral density (BMD) values were positively associated with physical activity but this was statistically significant (P = 0.050) only for adjusted values of spine BMD. Twenty-four healthy sedentary premenopausal women, subscribing to participate in a community exercise program lasting a month, and 18 age-matched controls were included in the longitudinal study. Serum osteocalcin and P1NP, but not sCTX, rose significantly, by ca. 25%, only in the active group after a month of exercise. The changes in the two bone formation markers remained statistically significant for values adjusted for body weight, which fell significantly in the exercise group. In conclusion, both the cross-sectional and the longitudinal parts of our study demonstrate that even minor changes in physical activity are associated with a clear effect on bone formation markers.
年轻人剧烈的体力活动对骨量和骨转换均有重要影响，但成年人适度体力活动的影响仍不明确。在一个大型队列（N = 530）的健康绝经前女性中，发现骨形成标志物（骨钙素和1型前胶原N端前肽[P1NP]）与体力活动水平显著相关，而1型胶原血清C端肽（sCTX）则不然，并且在按年龄和体重指数对数据进行调整（协方差分析）后，这种关联仍然显著。脊柱和髋部的平均骨矿物质密度（BMD）值与体力活动呈正相关，但仅脊柱BMD的调整值具有统计学意义（P = 0.050）。这项纵向研究纳入了24名同意参加为期一个月社区锻炼计划的久坐不动的健康绝经前女性，以及18名年龄匹配的对照者。仅在运动一个月后的活动组中，血清骨钙素和P1NP显著升高了约25%，而sCTX未升高。在对体重调整后，这两种骨形成标志物的变化仍具有统计学意义，运动组的体重显著下降。总之，我们研究的横断面和纵向部分均表明，即使体力活动的微小变化也会对骨形成标志物产生明显影响。
