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深入了解高渗甘油（HOG）途径组分Ssk2p、Pbs2p和Hog1p在机会性酵母葡萄牙念珠菌中的作用。

Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.

作者信息

Boisnard Stéphanie, Ruprich-Robert Gwenaël, Florent Martine, Da Silva Bruno, Chapeland-Leclerc Florence, Papon Nicolas

机构信息

Programme Chimiorésistance des Levures Pathogènes, EA209 Eucaryotes Pathogènes: Transports Membranaires et Chimiorésistance, UFR des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 75006 Paris, France.

出版信息

Eukaryot Cell. 2008 Dec;7(12):2179-83. doi: 10.1128/EC.00262-08. Epub 2008 Oct 24.

DOI:10.1128/EC.00262-08
PMID:18952902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2593183/
Abstract

In the present study, we have investigated the role of SSK2, PBS2, and HOG1, encoding modules of the high-osmolarity-glycerol mitogen-activated protein kinase pathway in Candida lusitaniae. Functional analysis of mutants indicated that Ssk2p, Pbs2p, and Hog1p are involved in osmotolerance, drug sensitivity, and heavy metal tolerance but not in oxidant stress adaptation.

摘要

在本研究中，我们研究了编码高渗甘油丝裂原活化蛋白激酶途径模块的SSK2、PBS2和HOG1在葡萄牙念珠菌中的作用。突变体的功能分析表明，Ssk2p、Pbs2p和Hog1p参与渗透压耐受性、药物敏感性和重金属耐受性，但不参与氧化应激适应。

相似文献

1
Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.深入了解高渗甘油（HOG）途径组分Ssk2p、Pbs2p和Hog1p在机会性酵母葡萄牙念珠菌中的作用。
Eukaryot Cell. 2008 Dec;7(12):2179-83. doi: 10.1128/EC.00262-08. Epub 2008 Oct 24.
2
Role of Sho1p adaptor in the pseudohyphal development, drugs sensitivity, osmotolerance and oxidant stress adaptation in the opportunistic yeast Candida lusitaniae.Sho1p衔接蛋白在机会性酵母葡萄牙念珠菌假菌丝发育、药物敏感性、渗透压耐受性及氧化应激适应中的作用
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Curr Microbiol. 2014 Dec;69(6):909-14. doi: 10.1007/s00284-014-0670-0. Epub 2014 Aug 14.
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本文引用的文献

1
Fphog1, a HOG-type MAP kinase gene, is involved in multistress response in Fusarium proliferatum.Fphog1是一种HOG型丝裂原活化蛋白激酶基因，参与了层出镰刀菌的多重应激反应。
J Basic Microbiol. 2008 Jun;48(3):151-9. doi: 10.1002/jobm.200700403.
2
Contributions of the response regulators Ssk1p and Skn7p in the pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.应答调节因子Ssk1p和Skn7p在机会性酵母葡萄牙念珠菌的假菌丝发育、应激适应及药物敏感性中的作用。
Eukaryot Cell. 2008 Jun;7(6):1071-4. doi: 10.1128/EC.00066-08. Epub 2008 Apr 11.
3
Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans.Ssk2丝裂原活化蛋白激酶激酶激酶调控新型隐球菌中应激激活的Hog1信号通路的不同模式。
Eukaryot Cell. 2007 Dec;6(12):2278-89. doi: 10.1128/EC.00349-07. Epub 2007 Oct 19.
4
Yeast osmoregulation.酵母渗透调节
Methods Enzymol. 2007;428:29-45. doi: 10.1016/S0076-6879(07)28002-4.
5
A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.单个丝裂原活化蛋白激酶激酶激酶（MAPKKK）调控致病性真菌白色念珠菌中的Hog1丝裂原活化蛋白激酶（MAPK）信号通路。
Mol Biol Cell. 2007 Nov;18(11):4603-14. doi: 10.1091/mbc.e07-06-0581. Epub 2007 Sep 5.
6
Differential involvement of histidine kinase receptors in pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.组氨酸激酶受体在机会性酵母葡萄牙念珠菌假菌丝发育、应激适应及药物敏感性中的差异作用。
Eukaryot Cell. 2007 Oct;6(10):1782-94. doi: 10.1128/EC.00155-07. Epub 2007 Jul 27.
7
The high-osmolarity glycerol response pathway in the human fungal pathogen Candida glabrata strain ATCC 2001 lacks a signaling branch that operates in baker's yeast.人类真菌病原体光滑念珠菌菌株ATCC 2001中的高渗甘油反应途径缺乏在酿酒酵母中起作用的信号分支。
Eukaryot Cell. 2007 Sep;6(9):1635-45. doi: 10.1128/EC.00106-07. Epub 2007 Jul 6.
8
The response regulator RRG-1 functions upstream of a mitogen-activated protein kinase pathway impacting asexual development, female fertility, osmotic stress, and fungicide resistance in Neurospora crassa.应答调节因子RRG-1在丝裂原活化蛋白激酶途径上游发挥作用，影响粗糙脉孢菌的无性发育、雌性育性、渗透胁迫和抗真菌剂能力。
Mol Biol Cell. 2007 Jun;18(6):2123-36. doi: 10.1091/mbc.e06-03-0226. Epub 2007 Mar 28.
9
The MAP kinase HwHog1 from the halophilic black yeast Hortaea werneckii: coping with stresses in solar salterns.来自嗜盐黑酵母沃尔尼氏霍塔酵母的丝裂原活化蛋白激酶HwHog1：应对盐场中的压力。
Saline Syst. 2007 Mar 9;3:3. doi: 10.1186/1746-1448-3-3.
10
Two mitogen-activated protein kinase signalling cascades mediate basal resistance to antifungal plant defensins in Fusarium graminearum.两条丝裂原活化蛋白激酶信号级联反应介导了禾谷镰刀菌对植物抗真菌防御素的基础抗性。
Cell Microbiol. 2007 Jun;9(6):1491-506. doi: 10.1111/j.1462-5822.2006.00887.x. Epub 2007 Jan 23.