Rosen Richard B, Hathaway Mark, Rogers John, Pedro Justin, Garcia Patricia, Dobre George M, Podoleanu Adrian Gh
Advanced Retinal Imaging Center, New York Eye and Ear Infirmary, New York, New York 10003, USA.
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):851-60. doi: 10.1167/iovs.08-1855. Epub 2008 Oct 24.
To evaluate how information from combined coronal optical coherence tomography (OCT) and confocal laser scanning ophthalmoscopy (SLO) with integrated simultaneous indocyanine green (ICG) dye angiography can be used in the diagnosis of a variety of macular diseases.
A compact chin-rest-based OCT/confocal imaging system was used to produce the OCT image and excite the fluorescence in the ICG dye. The same eye fundus area can be visualized with coronal (C-scans, en face) OCT and ICG angiography simultaneously. Fast T scanning (transverse scanning, en face) was used to build B- or C-scan OCT images along with confocal SLO views, with and without ICG filtration. The OCT, confocal SLO and ICG fluorescence images were simultaneously presented in a three-screen format. A live mixing channel overlaid the ICG sequence on the coronal OCT slices in a fourth panel for immediate comparison.
Thirty eyes were imaged. The pathologic conditions studied included classic and occult neovascular membranes, vascularized RPE detachments, polypoidal choroidal vasculopathy, traumatic choroidal rupture, diabetic maculopathy, central serous retinopathy, and macular drusen. Images were evaluated with special attention toward identifying novel relationships between morphology and function revealed by the superimposition of the studies.
Simultaneous visualization of an en face (coronal, C-scan) OCT image and of an ICG angiogram, displayed side by side and superimposed, permits more precise correlations between late fluorescence accumulation with structures deep to the retinal surface at the retina-choroid interface. The multiplanar scanning also permits immediate B-scan OCT cross-sectional views of regions of abnormal fluorescence. The paper demonstrates the synergy between the two types of studies, functional and anatomic, in providing a more complete view of the pathologic condition.
评估联合冠状光学相干断层扫描（OCT）和共焦激光扫描检眼镜（SLO）以及整合同步吲哚菁绿（ICG）染料血管造影所获得的信息如何用于诊断多种黄斑疾病。
使用基于紧凑型颏托的OCT/共焦成像系统来生成OCT图像并激发ICG染料中的荧光。同一眼底区域可通过冠状（C扫描，正面）OCT和ICG血管造影同时进行可视化。使用快速T扫描（横向扫描，正面）来构建B扫描或C扫描OCT图像以及共焦SLO视图，包括有和没有ICG滤光的情况。OCT、共焦SLO和ICG荧光图像以三屏格式同时呈现。一个实时混合通道在第四个面板中将ICG序列叠加在冠状OCT切片上以便立即进行比较。
对30只眼睛进行了成像。所研究的病理状况包括典型和隐匿性新生血管膜、血管化的视网膜色素上皮脱离、息肉样脉络膜血管病变、外伤性脉络膜破裂、糖尿病性黄斑病变、中心性浆液性视网膜病变和黄斑玻璃膜疣。对图像进行评估时特别关注识别这些研究叠加所揭示的形态与功能之间的新关系。
同时并排显示和叠加呈现正面（冠状，C扫描）OCT图像和ICG血管造影片，能够使视网膜 - 脉络膜界面处视网膜表面深层结构的晚期荧光积聚之间建立更精确的关联。多平面扫描还能立即获得异常荧光区域的B扫描OCT横截面视图。本文展示了功能和解剖学这两种研究类型在提供更完整病理状况视图方面的协同作用。
