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视网膜的多维正面光学相干断层扫描成像

Multidimensional en-face OCT imaging of the retina.

作者信息

Rosen Richard B, Hathaway Mark, Rogers John, Pedro Justin, Garcia Patricia, Laissue Philippe, Dobre George M, Podoleanu Adrian G

机构信息

Advanced Retinal Imaging Center, New York Eye and Ear Infirmary, New York, New York, USA.

出版信息

Opt Express. 2009 Mar 2;17(5):4112-33. doi: 10.1364/oe.17.004112.

DOI:10.1364/oe.17.004112
PMID:19259250
Abstract

Fast T-scanning (transverse scanning, en-face) was used to build B-scan or C-scan optical coherence tomography (OCT) images of the retina. Several unique signature patterns of en-face (coronal) are reviewed in conjunction with associated confocal images of the fundus and B-scan OCT images. Benefits in combining T-scan OCT with confocal imaging to generate pairs of OCT and confocal images similar to those generated by scanning laser ophthalmoscopy (SLO) are discussed in comparison with the spectral OCT systems. The multichannel potential of the OCT/SLO system is demonstrated with the addition of a third hardware channel which acquires and generates indocyanine green (ICG) fluorescence images. The OCT, confocal SLO and ICG fluorescence images are simultaneously presented in a two or a three screen format. A fourth channel which displays a live mix of frames of the ICG sequence superimposed on the corresponding coronal OCT slices for immediate multidimensional comparison, is also included. OSA ISP software is employed to illustrate the synergy between the simultaneously provided perspectives. This synergy promotes interpretation of information by enhancing diagnostic comparisons and facilitates internal correction of movement artifacts within C-scan and B-scan OCT images using information provided by the SLO channel.

摘要

快速T扫描(横向扫描,正面)用于构建视网膜的B扫描或C扫描光学相干断层扫描(OCT)图像。结合眼底相关共焦图像和B扫描OCT图像,对几种独特的正面(冠状)特征模式进行了综述。与光谱OCT系统相比,讨论了将T扫描OCT与共焦成像相结合以生成类似于扫描激光检眼镜(SLO)生成的OCT和共焦图像对的好处。通过添加第三个硬件通道来采集和生成吲哚菁绿(ICG)荧光图像,展示了OCT/SLO系统的多通道潜力。OCT、共焦SLO和ICG荧光图像以双屏或三屏格式同时呈现。还包括第四个通道,该通道显示叠加在相应冠状OCT切片上的ICG序列帧的实时混合,以便立即进行多维度比较。使用OSA ISP软件来说明同时提供的视角之间的协同作用。这种协同作用通过加强诊断比较促进信息解读,并利用SLO通道提供的信息促进C扫描和B扫描OCT图像内运动伪影的内部校正。

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