Venegas Mauricio, Muñoz Gabriela, Hurtado Carmen, Alvarez Luis, Velasco Marta, Villanueva Rodrigo A, Brahm Javier
Sección de Gastroenterología, Departamento de Medicina, Hospital Clínico de la Universidad de Chile, Av. Santos Dumont 999, Independencia, Santiago, Chile.
Arch Virol. 2008;153(11):2129-32. doi: 10.1007/s00705-008-0231-6. Epub 2008 Oct 25.
The eight genotypes (designated A-H) of hepatitis B virus (HBV) display distinctive geographical distribution worldwide, with genotypes A, D and F frequently detected in South America. To determine the prevalence of HBV genotypes in Santiago, Chile, 131 samples from chronic carriers were used for PCR amplification, and genotyping was performed by RFLP. The results indicated that genotype F was the most prevalent among HBV carries (84% of the cases), whereas genotypes A, B, C and D were found at a prevalence of 3.8, 3.8, 6.1, and 2.3%, respectively. We discuss these data in the complex scenario of HBV epidemiology.
乙型肝炎病毒（HBV）的八种基因型（命名为A - H）在全球呈现出独特的地理分布，其中基因型A、D和F在南美洲经常被检测到。为了确定智利圣地亚哥HBV基因型的流行情况，对131例慢性携带者的样本进行PCR扩增，并通过限制性片段长度多态性（RFLP）进行基因分型。结果表明，基因型F在HBV携带者中最为普遍（占病例的84%），而基因型A、B、C和D的流行率分别为3.8%、3.8%、6.1%和2.3%。我们在HBV流行病学的复杂背景下讨论了这些数据。
