Kearney N, McCann L, Norrie J, Taylor L, Gray P, McGee-Lennon M, Sage M, Miller M, Maguire R
Cancer Care Research Centre, Department of Nursing and Midwifery, University of Stirling, Stirling FK9 4LA, UK,
Support Care Cancer. 2009 Apr;17(4):437-44. doi: 10.1007/s00520-008-0515-0. Epub 2008 Oct 25.
To evaluate the impact of a mobile phone-based, remote monitoring, advanced symptom management system (ASyMS) on the incidence, severity and distress of six chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea) in patients with lung, breast or colorectal cancer.
A two group (intervention and control) by five time points (baseline, pre-cycle 2, pre-cycle 3, pre-cycle 4 and pre-cycle 5) randomised controlled trial.
Seven clinical sites in the UK; five specialist cancer centres and two local district hospitals.
One hundred and twelve people with breast, lung or colorectal cancer receiving outpatient chemotherapy.
A mobile phone-based, remote monitoring, advanced symptom management system (ASyMS).
Chemotherapy-related morbidity of six common chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea).
There were significantly higher reports of fatigue in the control group compared to the intervention group (odds ratio = 2.29, 95%CI = 1.04 to 5.05, P = 0.040) and reports of hand-foot syndrome were on average lower in the control group (odds ratio control/intervention = 0.39, 95%CI = 0.17 to 0.92, P = 0.031).
The study demonstrates that ASyMS can support the management of symptoms in patients with lung, breast and colorectal cancer receiving chemotherapy.
评估基于手机的远程监测、高级症状管理系统（ASyMS）对肺癌、乳腺癌或结直肠癌患者六种化疗相关症状（恶心、呕吐、疲劳、黏膜炎、手足综合征和腹泻）的发生率、严重程度和痛苦程度的影响。
一项两组（干预组和对照组）、五个时间点（基线、第2周期前、第3周期前、第4周期前和第5周期前）的随机对照试验。
英国的七个临床地点；五个专科癌症中心和两个当地地区医院。
112名接受门诊化疗的乳腺癌、肺癌或结直肠癌患者。
基于手机的远程监测、高级症状管理系统（ASyMS）。
六种常见化疗相关症状（恶心、呕吐、疲劳、黏膜炎、手足综合征和腹泻）的化疗相关发病率。
与干预组相比，对照组疲劳报告显著更多（优势比=2.29，95%置信区间=1.04至5.05，P=0.040），对照组手足综合征报告平均较少（对照组/干预组优势比=0.39，95%置信区间=0.17至0.92，P=0.031）。
该研究表明，ASyMS可支持接受化疗的肺癌、乳腺癌和结直肠癌患者的症状管理。
