Wrammert Jens, Ahmed Rafi
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Biol Chem. 2008 May;389(5):537-9. doi: 10.1515/bc.2008.066.
Long-lived plasma cells are key to maintaining long-term humoral immunity after infection or vaccination. Some vaccines and/or infections induce antibody levels that remain stable for the life of the individual. However, the mechanism whereby these long-lived plasma cells are maintained over long periods of time remains an open question. Furthermore, given a finite number of sustainable plasma cells within the bone marrow, it is also unclear how space for newly induced plasma cells is generated without compromising the pre-existing repertoire. Here we review the current understanding of these important issues.
长寿浆细胞是感染或接种疫苗后维持长期体液免疫的关键。一些疫苗和/或感染可诱导抗体水平在个体一生中保持稳定。然而，这些长寿浆细胞长期维持的机制仍是一个悬而未决的问题。此外，鉴于骨髓中可持续的浆细胞数量有限，新诱导产生的浆细胞如何在不影响已有细胞库的情况下获得生存空间也尚不清楚。在此，我们综述了目前对这些重要问题的理解。
