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Moloney leukemia virus immortalizes B lymphocytes in vitro.

作者信息

Runnels J, Serunian L, Thursby M, Rosenberg N

机构信息

Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.

出版信息

J Virol. 1991 Oct;65(10):5549-52. doi: 10.1128/JVI.65.10.5549-5552.1991.

DOI:10.1128/JVI.65.10.5549-5552.1991
PMID:1895405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC249058/
Abstract

An in vitro culture system in which Moloney murine leukemia virus induces immortalization of mature B lymphocytes has been developed. The cell lines derived in this way are nontumorigenic, and virus production is not required to sustain them. This system provides a new in vitro model with which to study the stepwise process of transformation by retroviruses lacking oncogenes.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/ab2e84272dce/jvirol00053-0435-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/e838ac556732/jvirol00053-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/6ac0fef5722c/jvirol00053-0435-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/ab2e84272dce/jvirol00053-0435-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/e838ac556732/jvirol00053-0434-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/6ac0fef5722c/jvirol00053-0435-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27a8/249058/ab2e84272dce/jvirol00053-0435-b.jpg

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本文引用的文献

1
Properties of a leukemia virus.一种白血病病毒的特性。
Natl Cancer Inst Monogr. 1960 Sep;4:7-37.
2
Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations.从肉瘤37中提取的一种淋巴白血病病毒的生物学研究。I. 起源与初步研究。
J Natl Cancer Inst. 1960 Apr;24:933-51.
3
Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.细胞质斑点杂交。对多个小细胞或组织样本中相对mRNA水平的简单分析。
J Biol Chem. 1982 Aug 10;257(15):8569-72.
4
Characterization of mouse monoclonal antibodies specific for Friend murine leukemia virus-induced erythroleukemia cells: friend-specific and FMR-specific antigens.针对弗氏鼠白血病病毒诱导的红白血病细胞的小鼠单克隆抗体的特性：弗氏特异性和FMR特异性抗原
Virology. 1981 Jul 15;112(1):131-44. doi: 10.1016/0042-6822(81)90619-x.
5
Multistep virus-induced leukemogenesis in vitro: description of a model specifying three steps within the myeloblastic malignant process.体外多步骤病毒诱导的白血病发生：一种确定髓母细胞恶性过程中三个步骤的模型描述。
Mol Cell Biol. 1984 Jan;4(1):216-20. doi: 10.1128/mcb.4.1.216-220.1984.
6
Malignant myeloblastic transformation of murine long-term bone marrow cultures by F-MuLV: in vitro reproduction of a long-term leukemogenesis, and investigation of preleukemic events.F-MuLV诱导小鼠长期骨髓培养物发生恶性成髓细胞转化：长期白血病发生的体外再现及白血病前期事件的研究
Int J Cancer. 1983 Aug 15;32(2):237-45. doi: 10.1002/ijc.2910320216.
7
The molecular genetics of cellular oncogenes.细胞癌基因的分子遗传学
Annu Rev Genet. 1984;18:553-612. doi: 10.1146/annurev.ge.18.120184.003005.
8
Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase.莫洛尼鼠白血病病毒突变体的分离与特性：一种用于检测病毒体逆转录酶释放的快速检测方法的应用
J Virol. 1981 Apr;38(1):239-48. doi: 10.1128/JVI.38.1.239-248.1981.
9
Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides.脂多糖在体外诱导免疫球蛋白和抗体合成
Eur J Immunol. 1972 Aug;2(4):349-53. doi: 10.1002/eji.1830020410.
10
Abelson virus potentiates long-term growth of mature B lymphocytes.阿贝尔森病毒可增强成熟B淋巴细胞的长期生长。
Mol Cell Biol. 1986 Jan;6(1):183-94. doi: 10.1128/mcb.6.1.183-194.1986.