Central Institute for Health Science, A.L.A. Corporation 40-14 Kitamachi, Seya-ku, Yokohama-city, Kanagawa, 246-0002 Japan.
Evid Based Complement Alternat Med. 2009 Sep;6(3):357-63. doi: 10.1093/ecam/nem126. Epub 2007 Oct 27.
The effects of lactic acid bacteria-fermented soybean extract (Biofermentics; BF) on experimental models of hepatic and renal disorders were investigated in vivo and in vitro. In rat, hepatitis induced by feeding of deoxycholic acid (DCA, 0.5 wt/wt, n = 6) or intraperitoneal injection of d-galactosamine (GMN, 500 mg/body wt, n = 6), the increase in serum AST (aspartate aminotransferase) and ALT (alanine aminotransferase) levels were inhibited significantly (P < 0.05) by feeding a diet containing 5% dried BF. Moreover, the BF-administered rat group showed lower concentrations of blood urea nitrogen and a larger amount of urine as compared with values in the control group. Pretreatment of primary cell cultures of rat hepatic and renal cells with BF prior to exposure to dichromate (K(2)Cr(2)O(7)) resulted in a marked decrease of dichromate-induced cytotoxicity as evaluated by the leakage of lactate dehydrogenase The levels of dichromate-induced lipid peroxidation, as monitored by malondialdehyde formation, were also reduced by pretreatment of hepatocytes with BF. These results suggest that BF may play a role in hepatic and renal disorders, and may be useful for maintaining health in humans as well.
将大豆提取物经乳酸菌发酵制成的产品（Biofermentics；BF）对肝、肾功能障碍的实验模型进行了体内和体外研究。在大鼠中，通过喂食脱氧胆酸（DCA，0.5wt/wt，n=6）或腹腔内注射半乳糖胺（GMN，500mg/体重，n=6）诱导肝炎，饲料中添加 5%的 BF 可显著抑制血清 AST（天冬氨酸转氨酶）和 ALT（丙氨酸转氨酶）水平的升高（P＜0.05）。此外，与对照组相比，BF 给药组的血尿素氮浓度较低，尿液量较大。在暴露于重铬酸钾（K2Cr2O7）之前，用 BF 预处理大鼠肝、肾细胞的原代细胞培养物，可显著降低由重铬酸盐诱导的细胞毒性，用丙二醛形成来监测，BF 预处理还降低了重铬酸盐诱导的脂质过氧化水平。这些结果表明，BF 可能在肝、肾功能障碍中发挥作用，并可能有助于维持人类健康。
