García-Juárez Ireri, Solórzano Santos Fortino, Alvarez-y-Muñoz María Teresa, Vázquez-Rosales José Guillermo
Servicio de Infectología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI IMSS, DF México.
Rev Invest Clin. 2008 Jul-Aug;60(4):292-6.
Twenty years ago, prevalence of Hepatitis A in Mexican children was 90%.
To describe a shift in the prevalence of Hepatitis A virus (HAV) infection and to demonstrate an increment in the age at the first contact with HAV, in a sample of Mexican children.
Reports of antiviral serologic studies collected from 1991 to 2005 from patients attending a pediatric hospital, were reviewed, and those with IgM anti-HAV positive in serum were selected. Age at the moment of acute infection was analyzed. Additionally, a serological survey searching IgG anti-HAV was made in a group of HAV unvaccinated children.
From 1708 determinations of IgM, 221 were positive (13%). According to the year of report, five groups were constituted. Mean age by group was: 1991-1993 of 6.4 years, 1994-1996 of 8.0, 1997-1999 of 8.4, 2000-2002 of 8.0 and from 2003-2005 of 10.1 years. In a cohort of 259 unvaccinated children (mean of age 8.59 years), IgG antibodies were detected in 51%.
In the infantile population studied a Hepatitis A epidemiology shift is suggested.
二十年前，墨西哥儿童甲型肝炎的患病率为90%。
描述甲型肝炎病毒（HAV）感染患病率的变化，并在一组墨西哥儿童样本中证明首次接触HAV的年龄有所增加。
回顾了1991年至2005年从一家儿科医院就诊患者中收集的抗病毒血清学研究报告，并选择血清中IgM抗-HAV呈阳性的患者。分析急性感染时的年龄。此外，对一组未接种HAV疫苗的儿童进行了抗-HAV IgG血清学调查。
在1708次IgM检测中，221次呈阳性（13%）。根据报告年份，分为五组。各组的平均年龄分别为：1991 - 1993年为6.4岁，1994 - 1996年为8.0岁，1997 - 1999年为8.4岁，2000 - 2002年为8.0岁，2003 - 2005年为10.1岁。在一组259名未接种疫苗的儿童（平均年龄8.59岁）中，51%检测到IgG抗体。
在所研究的儿童人群中提示甲型肝炎流行病学发生了变化。
