伊朗德黑兰不同年龄组儿童甲型肝炎病毒血清流行病学：对卫生政策的影响。

Seroepidemiology of hepatitis A virus in children of different age groups in Tehran, Iran: implications for health policy.

机构信息

Arak University of Medical Sciences, Arak, Iran.

出版信息

Travel Med Infect Dis. 2010 May;8(3):176-9. doi: 10.1016/j.tmaid.2010.02.004. Epub 2010 Mar 11.

DOI:10.1016/j.tmaid.2010.02.004

PMID:20541138

Abstract

BACKGROUND

Hepatitis A is one of the most frequently reported vaccine-preventable diseases throughout the world and remains endemic in many areas. Studies in various communities have shown that Hepatitis A virus (HAV) prevalence rises with age. The current data regarding hepatitis A epidemiology in Iran is limited. The aim of this study was to determine the seroepidemiology of hepatitis A in children of different age groups in Tehran, Iran.

METHODS

Plasma samples of 1065 children between ages of 6 months and 20 years were tested for the presence of total anti-HAV. The study population was stratified according to age.

RESULTS

The prevalence of total anti-HAV was 61.6%. HAV prevalence rates according to age groups were as follows: 61.5% between 6 months and 1.9 years, 51.7% between 2 and 5.9 years, 52.9% between 6 and 10.9 years, 65.2% between 11 and 15.9 years, 85% between 16 and 20 years. Total anti-HAV seroprevalence was significantly different between age groups.

CONCLUSION

The study findings indicate that hepatitis A is prevalent in children in Tehran, Iran and HAV infection is an important public health problem in this region.

摘要

背景

甲型肝炎是全球报告最频繁的疫苗可预防疾病之一，在许多地区仍然流行。在不同社区的研究表明，甲型肝炎病毒（HAV）的流行率随年龄增长而上升。目前有关伊朗甲型肝炎流行病学的数据有限。本研究旨在确定伊朗德黑兰不同年龄组儿童甲型肝炎的血清流行病学。

方法

检测了 1065 名 6 个月至 20 岁儿童的血浆样本中是否存在总抗-HAV。根据年龄对研究人群进行分层。

结果

总抗-HAV 的流行率为 61.6%。按年龄组划分的 HAV 流行率如下：6 个月至 1.9 岁为 61.5%，2 至 5.9 岁为 51.7%，6 至 10.9 岁为 52.9%，11 至 15.9 岁为 65.2%，16 至 20 岁为 85%。各年龄组之间的总抗-HAV 血清阳性率存在显著差异。