Busch Michael, Søreide Eldar
Department of Anaesthesiology and Intensive Care, Stavanger University Hospital, Stavanger, Norway.
Scand J Trauma Resusc Emerg Med. 2008 Sep 15;16:9. doi: 10.1186/1757-7241-16-9.
Numerous parameters and tests have been proposed for outcome prediction in comatose out-of-hospital cardiac arrest survivors. We conducted a survey of clinical practice of prognostication after therapeutic hypothermia (TH) became common practice in Norway.
By telephone, we interviewed the consultants who were in charge of the 25 ICUs admitting cardiac patients using 6 structured questions regarding timing, tests used and medical specialties involved in prognostication, as well as the clinical importance of the different parameters used and the application of TH in these patients.
Prognostication was conducted within 24-48 hours in the majority (72%) of the participating ICUs.The most commonly applied parameters and tests were a clinical neurological examination (100%), prehospital data (76%), CCT (56%) and EEG (52%). The parameters and tests considered to be of greatest importance for accurate prognostication were prehospital data (56%), neurological examination (52%), and EEG (20%).In 76% of the ICUs, a multidisciplinary approach to prognostication was applied, but only one ICU used a standardised protocol. Therapeutic hypothermia was in routine use in 80% of the surveyed ICUs.
Despite the routine use of TH, outcome prediction was performed early and was mainly based on prehospital information, neurological examination and CCT and EEG evaluation. Somatosensory evoked potentials appear to be underused and underrated, while the importance of prehospital data, CCT and EEG to appear to be overrated as methods for making accurate predictions.More evidence-based protocols for prognostication in cardiac arrest survivors, as well as additional studies on the effect of TH on known prognostic parameters are needed.
已提出众多参数和测试用于预测院外心脏骤停昏迷幸存者的预后。我们对治疗性低温(TH)在挪威成为常规治疗方法后预后评估的临床实践进行了一项调查。
通过电话,我们采访了负责25个收治心脏病患者的重症监护病房(ICU)的顾问,提出了6个结构化问题,涉及预后评估的时间、所使用的测试、涉及的医学专业,以及所使用的不同参数的临床重要性和TH在这些患者中的应用。
大多数(72%)参与调查的ICU在24 - 48小时内进行预后评估。最常用的参数和测试是临床神经学检查(100%)、院前数据(76%)、头颅计算机断层扫描(CCT,56%)和脑电图(EEG,52%)。被认为对准确预后评估最重要的参数和测试是院前数据(56%)、神经学检查(52%)和脑电图(20%)。在76%的ICU中,采用了多学科预后评估方法,但只有一个ICU使用了标准化方案。80%的被调查ICU常规使用治疗性低温。
尽管常规使用TH,但预后评估仍早期进行,主要基于院前信息、神经学检查以及CCT和EEG评估。体感诱发电位似乎未得到充分利用和重视,而院前数据、CCT和EEG作为准确预测方法的重要性似乎被高估。需要更多基于证据的心脏骤停幸存者预后评估方案,以及关于TH对已知预后参数影响的更多研究。