Hindman S H, Maynard J E, Bradley D W, Berquist K R, Denes A E
Am J Epidemiol. 1977 Feb;105(2):135-9. doi: 10.1093/oxfordjournals.aje.a112365.
The occurrence of a common source hepatitis A epidemic among the residents of a New England state mental institution where hepatitis B is hyperendemic provided an opportunity to observe concurrent infections with both agents. Nine HBsAg-positive individuals developed hepatitis A infections documented by hepatitis A antibody seroconversion in eight. The incidence of hepatitis A infections in susceptible HBsAg-positive persons (67%) did not differ from that in HBsAg-negative individuals (63%). The icteric to anicteric infection ratio in the HBsAG-positives (1:1.7) was similar to that in the negatives (1:2.1), and the clinical course in the antigen positives did not differ significantly from that of the antigen negatives. In addition to confirming previous reports that the viruses of hepatitis A and B are immunologically distinct, these results document that infection with either is independent of the other, and that the morbidity from simultaneous infection is no greater than that caused by either alone.
在乙型肝炎高度流行的新英格兰州立精神病院的居民中发生了一次甲型肝炎共同来源的流行，这为观察两种病原体的同时感染提供了机会。9名HBsAg阳性个体发生了甲型肝炎感染，其中8例通过甲型肝炎抗体血清学转换得到证实。易感的HBsAg阳性人群中甲型肝炎感染的发生率（67%）与HBsAg阴性个体（63%）没有差异。HBsAG阳性者中黄疸型与无黄疸型感染的比例（1:1.7）与阴性者（1:2.1）相似，抗原阳性者的临床病程与抗原阴性者没有显著差异。除了证实先前关于甲型和乙型肝炎病毒在免疫学上不同的报道外，这些结果还证明，感染其中一种病毒与另一种病毒无关，同时感染的发病率并不高于单独感染其中任何一种病毒所导致的发病率。
