Tenovuo J, Lumikari M, Soukka T
Department of Cariology, University of Turku, Finland.
Proc Finn Dent Soc. 1991;87(2):197-208.
Many antimicrobial agents in human saliva are known to have bacteriostatic or bactericidal effects on cariogenic bacteria, in particular against Streptococcus mutans. Studies have usually been conducted with purified agents (proteins) in vitro. Very little proof exists to show that they also affect oral cariogenic flora in vivo. Recent studies have shown that some salivary systems can act synergistically against Streptococcus mutans. Such synergistic antibacterial activity is likely to exist in the human mouth. Attempts to enhance the anticariogenic properties of saliva have been made by adding antimicrobial proteins such as peroxidase, lactoferrin and lysozyme to oral health products. Although clinical evidence is still limited, the idea of using such antimicrobial agents--"natural antibiotics"--rather than synthetic agents against cariogenic bacteria seems promising.
已知人类唾液中的许多抗菌剂对致龋菌具有抑菌或杀菌作用，尤其是对变形链球菌。研究通常是在体外使用纯化的抗菌剂（蛋白质）进行的。几乎没有证据表明它们在体内也会影响口腔致龋菌群。最近的研究表明，一些唾液系统可以协同作用对抗变形链球菌。这种协同抗菌活性很可能存在于人类口腔中。人们试图通过在口腔保健产品中添加过氧化物酶、乳铁蛋白和溶菌酶等抗菌蛋白来增强唾液的防龋特性。尽管临床证据仍然有限，但使用这类抗菌剂——“天然抗生素”——而非合成剂来对抗致龋菌的想法似乎很有前景。
