Unilever R&D Port Sunlight, Bebington, Wirral, CH63 3JW, UK.
Unilever R&D Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Sci Rep. 2017 Feb 27;7:43344. doi: 10.1038/srep43344.
The numerous species that make up the oral microbiome are now understood to play a key role in establishment and maintenance of oral health. The ability to taxonomically identify community members at the species level is important to elucidating its diversity and association to health and disease. We report the overall ecological effects of using a toothpaste containing enzymes and proteins compared to a control toothpaste on the plaque microbiome. The results reported here demonstrate that a toothpaste containing enzymes and proteins can augment natural salivary defences to promote an overall community shift resulting in an increase in bacteria associated with gum health and a concomitant decrease in those associated with periodontal disease. Statistical analysis shows significant increases in 12 taxa associated with gum health including Neisseria spp. and a significant decrease in 10 taxa associated with periodontal disease including Treponema spp. The results demonstrate that a toothpaste containing enzymes and proteins can significantly shift the ecology of the oral microbiome (at species level) resulting in a community with a stronger association to health.
目前已知，构成口腔微生物组的众多物种在口腔健康的建立和维持中起着关键作用。能够在物种水平上对群落成员进行分类鉴定对于阐明其多样性以及与健康和疾病的关联非常重要。我们报告了使用含有酶和蛋白质的牙膏与对照牙膏相比对菌斑微生物组的整体生态影响。这里报告的结果表明，含有酶和蛋白质的牙膏可以增强天然唾液防御能力，促进整体群落转变，导致与牙龈健康相关的细菌增加，同时与牙周病相关的细菌减少。统计分析显示，与牙龈健康相关的 12 个分类群（包括奈瑟氏菌属）显著增加，与牙周病相关的 10 个分类群（包括密螺旋体属）显著减少。结果表明，含有酶和蛋白质的牙膏可以显著改变口腔微生物组的生态（在物种水平上），导致与健康关联更强的群落。
