Dellon E S, Dellon A L
Division of Plastic Surgery, Johns Hopkins Hospital, Baltimore, Md.
Plast Reconstr Surg. 1991 Oct;88(4):686-94. doi: 10.1097/00006534-199110000-00020.
A laboratory approach to measuring neurologic impairment has been developed that is applicable to systemic disease as well as localized nerve injury. This approach compares individual parameters of the experimental rat hind footprint (walking track) with weight- and sex-matched control track parameters; classic mathematical indexing is not utilized. The normal track data obtained for the Sprague-Dawley rat showed a significant increase in print length (PL), toe spread (TS), and intermediate toe spread (ITS) with increasing rat weight. A significant difference between male and female rats above 400 gm also was noted. For a localized injury (sciatic nerve cut), this approach demonstrated that the contralateral hind footprint was a "compensated" rather than a normal track. This approach to track analysis also was capable of demonstrating progressive neurologic impairment for a sciatic nerve compression model and a systemic disease such as diabetes, as well as demonstrating reversal of these abnormal patterns when the "disease state" was treated.
一种用于测量神经功能损伤的实验室方法已被开发出来，它适用于全身性疾病以及局部神经损伤。这种方法将实验大鼠后足足迹（行走轨迹）的各个参数与体重和性别匹配的对照轨迹参数进行比较；未使用经典的数学索引法。对斯普拉格-道利大鼠获得的正常轨迹数据显示，随着大鼠体重增加，足印长度（PL）、趾展度（TS）和中间趾展度（ITS）显著增加。还注意到体重超过400克的雄性和雌性大鼠之间存在显著差异。对于局部损伤（坐骨神经切断），这种方法表明对侧后足足迹是一个“代偿性”而非正常轨迹。这种轨迹分析方法还能够显示坐骨神经压迫模型和糖尿病等全身性疾病的进行性神经功能损伤，以及在“疾病状态”得到治疗时这些异常模式的逆转。
