Electroanalytical characteristics of enoxacin and their analytical application.

In a 0.050 M HCl solution containing 0.12 M KCl, enoxacin yields a sensitive polarographic wave at -1.05 V, which can be used to determine trace amounts of the drug, the linear range being from 1.6 x 10(-8) to 1.6 x 10(-5) M with a detection limit of 6.25 x 10(-9) M. The electrochemical characteristics of the drug were studied by normal polarography, cyclic voltammetry and potentiostatic coulometry. A single-sweep polarographic procedure for the determination of enoxacin has been worked out and applied to urine and serum samples.