Kuo T L, Yu H Y
Department of Legal Medicine, College of Medicine, National Taiwan University, Taipei, Republic of China.
Toxicol Lett. 1991 Sep;58(1):107-15. doi: 10.1016/0378-4274(91)90196-d.
Rabbits that received paraquat (200 mg/kg) and ethanol (1.0-3.8 g/kg) by gavage resulted in shorter median survival times and higher mortality rates than those dosed with paraquat alone. Plasma paraquat levels in rabbits dosed with ethanol before, after and concurrently with ingestion of paraquat were significantly higher when compared with animals without ethanol intake. Furthermore, substantial differences in paraquat kinetics, higher AUC, lower total clearance (CL/F) and volume of distribution (V/F) were seen in the ethanol-paraquat group. The effect of ethanol on acute paraquat toxicity is, at least in part, associated with the increase in paraquat absorption and/or the decrease in paraquat excretion.
通过灌胃给予百草枯（200毫克/千克）和乙醇（1.0 - 3.8克/千克）的兔子，其中位生存时间比仅给予百草枯的兔子更短，死亡率更高。在摄入百草枯之前、之后以及同时给予乙醇的兔子，其血浆百草枯水平与未摄入乙醇的动物相比显著更高。此外，在乙醇 - 百草枯组中观察到百草枯动力学存在显著差异，曲线下面积（AUC）更高，总清除率（CL/F）和分布容积（V/F）更低。乙醇对急性百草枯毒性的影响至少部分与百草枯吸收增加和/或百草枯排泄减少有关。
