采用电分析方法测定原料药及药物制剂中抗蠕虫药双羟萘酸噻嘧啶
Determination of antihelminthic drug pyrantel pamoate in bulk and pharmaceutical formulations using electro-analytical methods.
作者信息
Jain Rajeev, Jadon Nimisha, Radhapyari Keisham
机构信息
School of Studies in Chemistry, Jiwaji University, Gwalior 474011, India.
出版信息
Talanta. 2006 Sep 15;70(2):383-6. doi: 10.1016/j.talanta.2006.02.061. Epub 2006 Jun 5.
Electrochemical behaviour of pyrantel pamoate has been studied by using different voltammetric and polarographic techniques in Britton Robinson buffer system. Differential pulse polarographic and cyclic voltammetric methods have been developed for the determination of drug in pharmaceutical formulation. A well-defined cathodic wave and one anodic peak were observed for the pyrantel pamoate in the entire pH range. Number of electrons transferred in the reduction process was calculated and the reduction mechanism postulated. The results indicate that the electrode process is reversible and diffusion controlled. The proposed method has been validated. The peak current is found to be linear over the concentration range 4x10(-4) to 2x10(-2)molL(-1). The lower detection limit (LOD) and lower limit of quantitation (LOQ) is found to be 2.45x10(-5) and 8x10(-5)molL(-1).
在 Britton Robinson 缓冲体系中，采用不同的伏安法和极谱法研究了双羟萘酸噻嘧啶的电化学行为。已开发出差示脉冲极谱法和循环伏安法用于测定药物制剂中的药物。在整个 pH 范围内，观察到双羟萘酸噻嘧啶有一个明确的阴极波和一个阳极峰。计算了还原过程中转移的电子数，并推测了还原机理。结果表明电极过程是可逆的且受扩散控制。所提出的方法已得到验证。发现峰电流在 4×10⁻⁴ 至 2×10⁻² molL⁻¹ 的浓度范围内呈线性。检测下限（LOD）和定量下限（LOQ）分别为 2.45×10⁻⁵ 和 8×10⁻⁵ molL⁻¹。
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